학술논문
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
Document Type
article
Author
Brouwer, Ingeborg; De Faire, Ulf; Eiriksdottir, Gudny; Ferrucci, Luigi; Forouhi, Nita; Geleijnse, Johanna; Hodge, Allison; Kimura, Hitomi; Laakso, Markku; Risérus, Ulf; van Westing, Anniek; Bandinelli, Stefania; Baylin, Ana; Giles, Graham; Gudnason, Vilmundur; Iso, Hiroyasu; Lemaitre, Rozenn; Ninomiya, Toshiharu; Post, Wendy; Psaty, Bruce; Salonen, Jukka; Schulze, Matthias; Tsai, Michael; Uusitupa, Matti; Wareham, Nicholas; Oh, Seung-Won; Wood, Alexis; Harris, William; Siscovick, David; Mozaffarian, Dariush; Leander, Karin; Laguzzi, Federica; Åkesson, Agneta; Marklund, Matti; Qian, Frank; Gigante, Bruna; Bartz, Traci; Bassett, Julie; Birukov, Anna; Campos, Hannia; Hirakawa, Yoichiro; Imamura, Fumiaki; Jäger, Susanne; Lankinen, Maria; Murphy, Rachel; Senn, Mackenzie; Tanaka, Toshiko; Tintle, Nathan; Virtanen, Jyrki; Yamagishi, Kazumasa; Allison, Matthew
Source
Circulation. 149(4)
Subject
Language
Abstract
BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions. CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.