학술논문
Association of Glycemia, Lipids, and Blood Pressure With Cognitive Performance in People With Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Document Type
article
Author
Luchsinger, José A; Younes, Naji; Manly, Jennifer J; Barzilay, Joshua; Valencia, Willy; Larkin, Mary E; Falck-Ytter, Corinna; Krause-Steinrauf, Heidi; Pop-Busui, Rodica; Florez, Hermes; Seaquist, Elizabeth; Crandall, Jill P; McKee, Melissa Diane; Brown-Friday, Janet; Xhori, Entila; Ballentine-Cargill, Keisha; Duran, Sally; Lukin, Jennifer; Beringher, Stephanie; Gonzalez de la torre, Susana; Phillips, Lawrence; Burgess, Elizabeth; Olson, Darin; Rhee, Mary; Wilson, Peter; Raines, Tasha Stephanie; Costello, Julie; Gullett, Chona; Maher-Albertelli, Maxine; Morehead, Folayan; Mungara, Radhika; Person, Saranjit; Savoye, Louise; Sibymon, Mabil; Tanukonda, Sridhar; White, Carol Ann; Holloway, Leah; Adams, Cynthia; Ross, April; Balasubramanyam, Ashok; Gonzalez, Erica; Wright, Charlyne; Hollander, Priscilla; Roe, Erin; Uy, Analyn; Burt, Polly; Estrada, Lorie; Chionh, Kris; Ismail-Beigi, Faramarz; Sayyed Kassem, Laure; Sood, Ajay; Tiktin, Margaret; Cramer, Bethany; Iacoboni, Jacalyn; Kononets, Maria V; Kulow, Tanya; Newman, Cynthia; Stancil, Katherine A; Sanders, Cristina; Tucker, Lisa; Werner, Amanda; Krol, Adrienne; McPhee, Gloria; Patel, Christine; Colosimo, Linda; Goland, Robin; Pring, James; Kringas, Patricia; Tejada, Jessica; Hausheer, Camille; Schneier, Harvey; Gumpel, Kelly; Kirpitch, Amanda; Green, Jennifer B; AbouAssi, Hiba; Chatterjee, Ranee; Feinglos, Mark N; English Jones, Jennifer; Khan, Shubi A; Kimpel, Jeanne B; Zimmer, Ronna P; Furst, Mary; Satterwhite, Barbara M; Thacker, Connie R; Evans Kreider, Kathryn; Mather, Kieren J; Lteif, Amale; Hamilton, Tonya; Patel, Nick; Riera, Gabriela; Jackson, Marcia; Pirics, Vivian; Howard, Devin; Aguillar, Danielle; Hurt, Sloan; Bergenstal, Richard; Carlson, Anders; Martens, Thomas; Johnson, Mary
Source
Diabetes Care. 44(10)
Subject
Language
Abstract
ObjectiveType 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methodsCross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A1c [HbA1c]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST).ResultsAmong 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA1c was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition.ConclusionsIn people with type 2 diabetes of a mean duration of