학술논문
Global disparities in SARS-CoV-2 genomic surveillance
Document Type
article
Author
Brito, Anderson F; Semenova, Elizaveta; Dudas, Gytis; Hassler, Gabriel W; Kalinich, Chaney C; Kraemer, Moritz UG; Ho, Joses; Tegally, Houriiyah; Githinji, George; Agoti, Charles N; Matkin, Lucy E; Whittaker, Charles; Howden, Benjamin P; Sintchenko, Vitali; Zuckerman, Neta S; Mor, Orna; Blankenship, Heather M; de Oliveira, Tulio; Lin, Raymond TP; Siqueira, Marilda Mendonça; Resende, Paola Cristina; Vasconcelos, Ana Tereza R; Spilki, Fernando R; Aguiar, Renato Santana; Alexiev, Ivailo; Ivanov, Ivan N; Philipova, Ivva; Carrington, Christine VF; Sahadeo, Nikita SD; Branda, Ben; Gurry, Céline; Maurer-Stroh, Sebastian; Naidoo, Dhamari; von Eije, Karin J; Perkins, Mark D; van Kerkhove, Maria; Hill, Sarah C; Sabino, Ester C; Pybus, Oliver G; Dye, Christopher; Bhatt, Samir; Flaxman, Seth; Suchard, Marc A; Grubaugh, Nathan D; Baele, Guy; Faria, Nuno R
Source
Nature Communications. 13(1)
Subject
Language
Abstract
Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced >0.5% of their COVID-19 cases, while 42% of low- and middle-income countries reached that mark. Around 25% of the genomes from high income countries were submitted within 21 days, a pattern observed in 5% of the genomes from low- and middle-income countries. We found that sequencing around 0.5% of the cases, with a turnaround time