학술논문
Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
Document Type
article
Author
Lewis, Nathaniel M; Naioti, Eric A; Self, Wesley H; Ginde, Adit A; Douin, David J; Talbot, H Keipp; Casey, Jonathan D; Mohr, Nicholas M; Zepeski, Anne; Gaglani, Manjusha; Ghamande, Shekhar A; McNeal, Tresa A; Shapiro, Nathan I; Gibbs, Kevin W; Files, D Clark; Hager, David N; Shehu, Arber; Prekker, Matthew E; Erickson, Heidi L; Gong, Michelle N; Mohamed, Amira; Henning, Daniel J; Steingrub, Jay S; Peltan, Ithan D; Brown, Samuel M; Martin, Emily T; Hubel, Kinsley; Hough, Catherine L; Busse, Laurence W; Lohuis, Caitlin C ten; Duggal, Abhijit; Wilson, Jennifer G; Gordon, Alexandra J; Qadir, Nida; Chang, Steven Y; Mallow, Christopher; Rivas, Carolina; Babcock, Hilary M; Kwon, Jennie H; Exline, Matthew C; Halasa, Natasha; Chappell, James D; Lauring, Adam S; Grijalva, Carlos G; Rice, Todd W; Rhoads, Jillian P; Stubblefield, William B; Baughman, Adrienne; Womack, Kelsey N; Lindsell, Christopher J; Hart, Kimberly W; Zhu, Yuwei; Schrag, Stephanie J; Kobayashi, Miwako; Verani, Jennifer R; Patel, Manish M; Tenforde, Mark W; Collaborators, IVY Network; McNeal, Tresa; Ghamande, Shekhar; Calhoun, Nicole; Murthy, Kempapura; Herrick, Judy; McKillop, Amanda; Hoffman, Eric; Zayed, Martha; Smith, Michael; Settele, Natalie; Ettlinger, Jason; Priest, Elisa; Thomas, Jennifer; Arroliga, Alejandro; Beeram, Madhava; Kindle, Ryan; Kozikowski, Lori-Ann; De Souza, Lesley; Ouellette, Scott; Thornton-Thompson, Sherell; Tyler, Patrick; Mehkri, Omar; Mitchell, Meg; Brennan, Connery; Ashok, Kiran; Poynter, Bryan; Stanley, Nicholas; Hendrickson, Audrey; Caspers, Sean; Scharber, Tyler; Jorgensen, Jeffrey; Bowers, Robert; King, Jennifer; Aston, Valerie; Armbruster, Brent; Rothman, Richard E; Nair, Rahul; Chen, Jen-Ting; Karow, Sarah; Robart, Emily; Maldonado, Paulo Nunes; Khan, Maryiam
Source
The Journal of Infectious Diseases. 225(10)
Subject
Language
Abstract
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.