학술논문
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.
Document Type
article
Author
Docherty, Anna; Mullins, Niamh; Ashley-Koch, Allison; Qin, Xuejun; Coleman, Jonathan; Shabalin, Andrey; Kang, JooEun; Murnyak, Balasz; Wendt, Frank; Adams, Mark; Campos, Adrian; DiBlasi, Emily; Fullerton, Janice; Kranzler, Henry; Bakian, Amanda; Monson, Eric; Rentería, Miguel; Walss-Bass, Consuelo; Andreassen, Ole; Behera, Chittaranjan; Bulik, Cynthia; Edenberg, Howard; Kessler, Ronald; Mann, J; Nurnberger, John; Pistis, Giorgio; Streit, Fabian; Ursano, Robert; Polimanti, Renato; Dennis, Michelle; Garrett, Melanie; Hair, Lauren; Harvey, Philip; Hauser, Elizabeth; Hauser, Michael; Huffman, Jennifer; Jacobson, Daniel; Madduri, Ravi; McMahon, Benjamin; Oslin, David; Trafton, Jodie; Awasthi, Swapnil; Berrettini, Wade; Bohus, Martin; Chang, Xiao; Chen, Hsi-Chung; Chen, Wei; Christensen, Erik; Crow, Scott; Duriez, Philibert; Edwards, Alexis; Fernández-Aranda, Fernando; Galfalvy, Hanga; Gandal, Michael; Gorwood, Philip; Guo, Yiran; Hafferty, Jonathan; Hakonarson, Hakon; Halmi, Katherine; Hishimoto, Akitoyo; Jain, Sonia; Jamain, Stéphane; Jiménez-Murcia, Susana; Johnson, Craig; Kaplan, Allan; Kaye, Walter; Keel, Pamela; Kennedy, James; Kim, Minsoo; Klump, Kelly; Levey, Daniel; Li, Dong; Liao, Shih-Cheng; Lieb, Klaus; Lilenfeld, Lisa; Marshall, Christian; Mitchell, James; Okazaki, Satoshi; Otsuka, Ikuo; Pinto, Dalila; Powers, Abigail; Ramoz, Nicolas; Ripke, Stephan; Roepke, Stefan; Rozanov, Vsevolod; Scherer, Stephen; Schmahl, Christian; Sokolowski, Marcus; Starnawska, Anna; Strober, Michael; Su, Mei-Hsin; Thornton, Laura; Treasure, Janet; Ware, Erin; Watson, Hunna; Witt, Stephanie; Woodside, D; Yilmaz, Zeynep; Zillich, Lea; Adolfsson, Rolf
Source
American Journal of Psychiatry. 180(10)
Subject
Language
Abstract
OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. METHODS: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. RESULTS: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values