학술논문
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
Document Type
article
Author
Smith, Eric E; Biessels, Geert Jan; De Guio, François; de Leeuw, Frank Erik; Duchesne, Simon; Düring, Marco; Frayne, Richard; Ikram, M Arfan; Jouvent, Eric; MacIntosh, Bradley J; Thrippleton, Michael J; Vernooij, Meike W; Adams, Hieab; Backes, Walter H; Ballerini, Lucia; Black, Sandra E; Chen, Christopher; Corriveau, Rod; DeCarli, Charles; Greenberg, Steven M; Gurol, M Edip; Ingrisch, Michael; Job, Dominic; Lam, Bonnie YK; Launer, Lenore J; Linn, Jennifer; McCreary, Cheryl R; Mok, Vincent CT; Pantoni, Leonardo; Pike, G Bruce; Ramirez, Joel; Reijmer, Yael D; Romero, Jose Rafael; Ropele, Stefan; Rost, Natalia S; Sachdev, Perminder S; Scott, Christopher JM; Seshadri, Sudha; Sharma, Mukul; Sourbron, Steven; Steketee, Rebecca ME; Swartz, Richard H; van Oostenbrugge, Robert; van Osch, Matthias; van Rooden, Sanneke; Viswanathan, Anand; Werring, David; Dichgans, Martin; Wardlaw, Joanna M
Source
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring. 11(1)
Subject
Language
Abstract
IntroductionMany consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.MethodsSurveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.ResultsA framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.ConclusionsThe HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.