학술논문
Discrimination And Calibration Of The Vacs Index 2.0 For Predicting Mortality Among People With Hiv In North America
Document Type
article
Author
McGinnis, Kathleen A; Justice, Amy C; Moore, Richard D; Silverberg, Michael J; Althoff, Keri N; Karris, Maile; Lima, Viviane D; Crane, Heidi M; Horberg, Michael A; Klein, Marina B; Gange, Stephen J; Gebo, Kelly A; Mayor, Angel; Tate, Janet P; Benson, Constance A; Bosch, Ronald J; Kirk, Gregory D; Marconi, Vincent; Colasanti, Jonathan; Mayer, Kenneth H; Grasso, Chris; Hogg, Robert S; Montaner, Julio SG; Sereda, Paul; Salters, Kate; Buchacz, Kate; Li, Jun; Jacobson, Jeffrey M; Thorne, Jennifer E; Brown, Todd; Tien, Phyllis; D’Souza, Gypsyamber; Smith, Graham; Loutfy, Mona; Gupta, Meenakshi; Rabkin, Charles; Kroch, Abigail; Burchell, Ann; Betts, Adrian; Lindsay, Joanne; Nijhawan, Ank; Mayor, Angel M; Gill, M John; Martin, Jeffrey N; Brooks, John T; Saag, Michael S; Mugavero, Michael J; Willig, James; Bamford, Laura; Eron, Joseph J; Napravnik, Sonia; Kitahata, Mari M; Sterling, Timothy R; Haas, David; Rebeiro, Peter; Turner, Megan; Lee, Jennifer S; McKaig, Rosemary G; Freeman, Aimee M; Van Rompaey, Stephen E; Morton, Liz; McReynolds, Justin; Lober, William B; Hogan, Brenna; You, Bin; Humes, Elizabeth; Gerace, Lucas; Stewart, Cameron; Coburn, Sally
Source
Clinical Infectious Diseases. 75(2)
Subject
Language
Abstract
BackgroundThe updated Veterans Aging Cohort Study (VACS) Index 2.0 combines general and human immunodeficiency virus (HIV)-specific biomarkers to generate a continuous score that accurately discriminates risk of mortality in diverse cohorts of persons with HIV (PWH), but a score alone is difficult to interpret. Using data from the North American AIDS Cohort Collaboration (NA-ACCORD), we translate VACS Index 2.0 scores into validated probability estimates of mortality.MethodsBecause complete mortality ascertainment is essential for accurate calibration, we restricted analyses to cohorts with mortality from the National Death Index or equivalent sources. VACS Index 2.0 components were ascertained from October 1999 to April 2018. Mortality was observed up to March 2019. Calibration curves compared predicted (estimated by fitting a gamma model to the score) to observed mortality overall and within subgroups: cohort (VACS/NA-ACCORD subset), sex, age 500 copies/mL, CD4 count