학술논문
Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women
Document Type
article
Author
Wang, Xiaoliang; Kapoor, Pooja Middha; Auer, Paul L; Dennis, Joe; Dunning, Alison M; Wang, Qin; Lush, Michael; Michailidou, Kyriaki; Bolla, Manjeet K; Aronson, Kristan J; Murphy, Rachel A; Brooks-Wilson, Angela; Lee, Derrick G; Cordina-Duverger, Emilie; Guénel, Pascal; Truong, Thérèse; Mulot, Claire; Teras, Lauren R; Patel, Alpa V; Dossus, Laure; Kaaks, Rudolf; Hoppe, Reiner; Lo, Wing-Yee; Brüning, Thomas; Hamann, Ute; Czene, Kamila; Gabrielson, Marike; Hall, Per; Eriksson, Mikael; Jung, Audrey; Becher, Heiko; Couch, Fergus J; Larson, Nicole L; Olson, Janet E; Ruddy, Kathryn J; Giles, Graham G; MacInnis, Robert J; Southey, Melissa C; Le Marchand, Loic; Wilkens, Lynne R; Haiman, Christopher A; Olsson, Håkan; Augustinsson, Annelie; Krüger, Ute; Wagner, Philippe; Scott, Christopher; Winham, Stacey J; Vachon, Celine M; Perou, Charles M; Olshan, Andrew F; Troester, Melissa A; Hunter, David J; Eliassen, Heather A; Tamimi, Rulla M; Brantley, Kristen; Andrulis, Irene L; Figueroa, Jonine; Chanock, Stephen J; Ahearn, Thomas U; García-Closas, Montserrat; Evans, Gareth D; Newman, William G; van Veen, Elke M; Howell, Anthony; Wolk, Alicja; Håkansson, Niclas; Anton-Culver, Hoda; Ziogas, Argyrios; Jones, Michael E; Orr, Nick; Schoemaker, Minouk J; Swerdlow, Anthony J; Kitahara, Cari M; Linet, Martha; Prentice, Ross L; Easton, Douglas F; Milne, Roger L; Kraft, Peter; Chang-Claude, Jenny; Lindström, Sara
Source
Scientific Reports. 12(1)
Subject
Language
Abstract
Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values