학술논문

FGF23, Frailty, and Falls in SPRINT
Document Type
article
Source
Journal of the American Geriatrics Society. 69(2)
Subject
Aging
Clinical Trials and Supportive Activities
Kidney Disease
Hypertension
Clinical Research
Prevention
Accidental Falls
Aged
Biomarkers
Correlation of Data
Cross-Sectional Studies
Female
Fibroblast Growth Factor-23
Fibroblast Growth Factors
Frailty
Glomerular Filtration Rate
Humans
Male
Renal Insufficiency
Chronic
fibroblast growth factor 23
falls
frailty
chronic kidney disease
biomarkers
Medical and Health Sciences
Geriatrics
Language
Abstract
Background/objectivesChronic kidney disease (CKD) is associated with frailty. Fibroblast growth factor 23 (FGF23) is elevated in CKD and associated with frailty among non-CKD older adults and individuals with human immunodeficiency virus. Whether FGF23 is associated with frailty and falls in CKD is unknown.DesignCross-sectional and longitudinal observational study.SettingSystolic Blood Pressure Intervention Trial (SPRINT), a randomized trial evaluating standard (systolic blood pressure [SBP]