학술논문
Immunosurveillance of senescent cancer cells by natural killer cells
Document Type
article
Author
Source
OncoImmunology. 3(2)
Subject
Language
Abstract
We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program.