학술논문
Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.
Document Type
article
Author
Nasr, Zahra; Schoeps, Vinicius Andreoli; Ziaei, Amin; Virupakshaiah, Akash; Adams, Cameron; Casper, T Charles; Waltz, Michael; Rose, John; Rodriguez, Moses; Tillema, Jan-Mendelt; Chitnis, Tanuja; Graves, Jennifer S; Benson, Leslie; Rensel, Mary; Krupp, Lauren; Waldman, Amy T; Weinstock-Guttman, Bianca; Lotze, Tim; Greenberg, Benjamin; Aaen, Gregory; Mar, Soe; Schreiner, Teri; Hart, Janace; Simpson-Yap, Steve; Mesaros, Clementina; Barcellos, Lisa F; Waubant, Emmanuelle
Source
Journal of neurology, neurosurgery, and psychiatry. 94(7)
Subject
Language
Abstract
BackgroundWe previously reported an association between household chemical exposures and an increased risk of paediatric-onset multiple sclerosis.MethodsUsing a case-control paediatric multiple sclerosis study, gene-environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis was estimated.Genetic risk factors of interest included the two major HLA multiple sclerosis risk factors, the presence of DRB1*15 and the absence of A*02, and multiple sclerosis risk variants within the metabolic pathways of common household toxic chemicals, including IL-6 (rs2069852), BCL-2 (rs2187163) and NFKB1 (rs7665090).Results490 paediatric-onset multiple sclerosis cases and 716 controls were included in the analyses. Exposures to insect repellent for ticks or mosquitos (OR 1.47, 95% CI 1.06 to 2.04, p=0.019), weed control products (OR 2.15, 95% CI 1.51 to 3.07, p