학술논문
Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium
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article
Author
Chang, Alex R; Grams, Morgan E; Ballew, Shoshana H; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D; Roderick, Paul J; Valdivielso, Jose M; Visseren, Frank LJ; Zhang, Luxia; Gansevoort, Ron T; Hallan, Stein I; Levey, Andrew S; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark; Astor, Brad; Appel, Larry; Greene, Tom; Chen, Teresa; Chalmers, John; Arima, Hisatomi; Perkovic, Vlado; Yatsuya, Hiroshi; Tamakoshi, Koji; Hirakawa, Yoshihisa; Coresh, Josef; Sang, Yingying; Polkinghorne, Kevan; Chadban, Steven; Atkins, Robert; Levin, Adeera; Djurdjev, Ognjenka; Klein, Ron; Lee, Kristine; Liu, Lisheng; Zhao, Minghui; Wang, Fang; Wang, Jinwei; Tang, Mila; Heine, Gunnar; Emrich, Insa; Zawada, Adam; Bauer, Lucie; Nally, Joseph; Schold, Jesse; Shlipak, Michael; Sarnak, Mark; Katz, Ronit; Hiramoto, Jade; Iso, Hiroyasu; Yamagishi, Kazumasa; Umesawa, Mitsumasa; Muraki, Isao; Fukagawa, Masafumi; Maruyama, Shoichi; Hamano, Takayuki; Hasegawa, Takeshi; Fujii, Naohiko; Jafar, Tazeen; Hatcher, Juanita; Poulter, Neil; Chaturvedi, Nish; Wheeler, David; Emberson, John; Townend, John; Landray, Martin; Brenner, Hermann; Schöttker, Ben; Saum, Kai-Uwe; Rothenbacher, Dietrich; Fox, Caroline; Hwang, Shih-Jen; Köttgen, Anna; Schneider, Markus P; Eckardt, Kai-Uwe; Green, Jamie; Kirchner, H Lester; Ito, Sadayoshi; Miyazaki, Mariko; Nakayama, Masaaki; Yamada; Cirillo, Massimo; Romundstad, Solfrid; Øvrehus, Marius; Langlo, Knut Asbjørn; Irie, Fujiko; Sairenchi, Toshimi; Rebholz, Casey M; Young, Bessie
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Abstract
ObjectiveTo evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.DesignIndividual participant data meta-analysis.SettingCohorts from 40 countries with data collected between 1970 and 2017.ParticipantsAdults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84 417); and 18 cohorts with chronic kidney disease (n=91 607).Main outcome measuresGFR decline (estimated GFR decline ≥40%, initiation of kidney replacement therapy or estimated GFR