학술논문
Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease
Document Type
article
Author
Baker, Anna M; Holbrook, Janet T; Yohannes, Abebaw M; Eakin, Michelle N; Sugar, Elizabeth A; Henderson, Robert J; Casper, Anne S; Kaminsky, David A; Rea, Alexis L; Mathews, Anne M; Que, Loretta G; Ramsdell, Joe W; Gerald, Lynn B; Wise, Robert A; Hanania, Nicola A; Hanania, Nicola; Sockrider, Marianna; Bertrand, Laura; Atik, Mustafa; Lopez, Blanca A; Reibman, Joan; DiMango, Emily; Rogers, Linda; Carapetyan, Karen; Rivera, Kristina; Scheuerman, Melissa; Fiorino, Elizabeth; Bryce-Robinson, Newel; Green, Deanna; Noveck, Robert; Foss, Catherine; Ghidorzi, Jessica; Wang, Zongyao; Pangborn, Elise; Robertson, V Susan; Eberlein, Nicholas; Stiles, Jane; Land, Michael; Vickery, Brian; Wu, Eveline; Jaggers, Denise; Allen, Stephanie; Mervin-Blake, Sabrena; Smith, Lewis; Kalhan, Ravi; Moy, James; Naureckas, Edward; Hixon, Jenny; Gonsalves, Zenobia; Zagaja, Virginia; Kustwin, Jennifer; Xu, Ben; Matthews, Thomas; Robinson, Lucius; Singh, Noopur; Happel, Kyle; Sandi, Marie C; Graham, Jennifer M; Sullivan, Katelyn; Poretta, Elizabeth; Katial, Rohit; Hoyte, Flavia; Rojas, Maria; Castro, Mario; Bacharier, Leonard B; Sumino, Kaharu; Yusen, Roger D; Tarsi, Jaime J; Patterson, Brenda; Montgomery, Terri; Busk, Michael; Weiss, Debra; Sundblad, Kimberly; Irvin, Charles; Dixon, Anne E; Teneback, Charlotte; Kanagalingam, Jothi; Burns, Stephanie M; Dwinell, Kathleen; Goodwin, James L; Brown, Mark A; Carr, Tara F; Berry, Cristine E; Bime, Christian; Goforth, Mark A; Ryan, Elizabeth A; Wences, Jesus A; Lopez, Silvia L; Priefert, Janette C; Provencio-Dean, Natalie S; Ogas, Destinee R; Bloss, Valerie R; Wasserman, Stephen I; Soler, Xavier T; Kinninger, Katie H; Martineau, Amber J
Source
Annals of the American Thoracic Society. 15(8)
Subject
Language
Abstract
Rationale: Anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires: the Generalized Anxiety Disorder 7-Item Scale (GAD-7), the Hospital Anxiety and Depression Scale Anxiety subscale (HADS-A), and the Anxiety Inventory for Respiratory Disease (AIR).Objectives: To evaluate and compare the test performance characteristics of three anxiety screening questionnaires, using the Mini-International Neuropsychiatric Interview (MINI), version 7.0, as the "gold standard."Methods: Individuals with COPD were recruited at 16 centers. The MINI and questionnaires were administered by trained research coordinators at an in-person visit and readministered by telephone 2-4 weeks later. A composite score for the presence of any Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) anxiety disorder was computed, based on the MINI as the gold standard, compared with a participant screening positive on self-report measures for these analyses.Results: Two hundred and twenty eligible individuals with COPD were enrolled; 219 completed the study. Eleven percent were identified as having a DSM-V anxiety disorder, based on the MINI. Elevated anxiety symptoms based on questionnaires were 38% for the AIR, 30% for the GAD-7, and 20% for the HADS-A. Area under the receiver operating characteristic curve (AUC) was highest for the GAD-7 (0.78; 95% confidence interval [CI], 0.69-0.87), followed by the HADS-A (0.74; 95% CI, 0.64-0.84) and the AIR (0.66; 95% CI, 0.56-0.76). The AUC for the GAD-7 was significantly greater than for the AIR (P = 0.014). Sensitivity was not statistically different among the questionnaires: 77% for the GAD-7, 63% for the HADS-A, and 66% for the AIR. The HADS-A had the highest specificity, 85%, which was significantly higher than that of the GAD-7 (77%; P