학술논문
A metabolomic signature of the APOE2 allele
Document Type
article
Author
Sebastiani, Paola; Song, Zeyuan; Ellis, Dylan; Tian, Qu; Schwaiger-Haber, Michaela; Stancliffe, Ethan; Lustgarten, Michael S; Funk, Cory C; Baloni, Priyanka; Yao, Cong-Hui; Joshi, Shakchhi; Marron, Megan M; Gurinovich, Anastasia; Li, Mengze; Leshchyk, Anastasia; Xiang, Qingyan; Andersen, Stacy L; Feitosa, Mary F; Ukraintseva, Svetlana; Soerensen, Mette; Fiehn, Oliver; Ordovas, Jose M; Haigis, Marcia; Monti, Stefano; Barzilai, Nir; Milman, Sofiya; Ferrucci, Luigi; Rappaport, Noa; Patti, Gary J; Perls, Thomas T
Source
GeroScience. 45(1)
Subject
Language
Abstract
With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants. This consortium includes the New England Centenarian Study, the Baltimore Longitudinal Study of Aging, the Arivale study, the Longevity Genes Project/LonGenity studies, and the Long Life Family Study. We analyzed the association between APOE genotype groups E2 (e2e2 and e2e3 genotypes, N = 544), E3 (e3e3 genotypes, N = 2299), and E4 (e3e4 and e4e4 genotypes, N = 702) with metabolite profiles in the five studies and used fixed effect meta-analysis to aggregate the results. Our meta-analysis identified a signature of 19 metabolites that are significantly associated with the E2 genotype group at FDR