학술논문
Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis
Document Type
article
Author
Berthiller, Julien; Straif, Kurt; Agudo, Antonio; Ahrens, Wolfgang; dos Santos, Alexandre Bezerra; Boccia, Stefania; Cadoni, Gabriella; Canova, Cristina; Castellsague, Xavier; Chen, Chu; Conway, David; Curado, Maria Paula; Dal Maso, Luigino; Daudt, Alexander W; Fabianova, Eleonora; Fernandez, Leticia; Franceschi, Silvia; Fukuyama, Erica E; Hayes, Richard B; Healy, Claire; Herrero, Rolando; Holcatova, Ivana; Kelsey, Karl; Kjaerheim, Kristina; Koifman, Sergio; Lagiou, Pagona; La Vecchia, Carlo; Lazarus, Philip; Levi, Fabio; Lissowska, Jolanta; Macfarlane, Tatiana; Mates, Dana; McClean, Michael; Menezes, Ana; Merletti, Franco; Morgenstern, Hal; Muscat, Joshua; Olshan, Andrew F; Purdue, Mark; Ramroth, Heribert; Rudnai, Peter; Schwartz, Stephen M; Serraino, Diego; Shangina, Oxana; Smith, Elaine; Sturgis, Erich M; Szeszenia-Dabrowska, Neonila; Thomson, Peter; Vaughan, Thomas L; Vilensky, Marta; Wei, Qingyi; Winn, Deborah M; Wünsch-Filho, Victor; Zhang, Zuo-Feng; Znaor, Ariana; Ferro, Gilles; Brennan, Paul; Boffetta, Paolo; Hashibe, Mia; Lee, Yuan-Chin Amy
Source
International Journal of Epidemiology. 45(3)
Subject
Language
Abstract
BackgroundCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (0-3, >3-5, >5-10 cigarettes per day.ResultsSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.ConclusionOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.