학술논문
Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
Document Type
article
Author
Sarnowski, Chloé; Ghanbari, Mohsen; Bis, Joshua C; Logue, Mark; Fornage, Myriam; Mishra, Aniket; Ahmad, Shahzad; Beiser, Alexa S; Boerwinkle, Eric; Bouteloup, Vincent; Chouraki, Vincent; Cupples, L Adrienne; Damotte, Vincent; DeCarli, Charles S; DeStefano, Anita L; Djoussé, Luc; Fohner, Alison E; Franz, Carol E; Kautz, Tiffany F; Lambert, Jean-Charles; Lyons, Michael J; Mosley, Thomas H; Mukamal, Kenneth J; Pase, Matthew P; Portilla Fernandez, Eliana C; Rissman, Robert A; Satizabal, Claudia L; Vasan, Ramachandran S; Yaqub, Amber; Debette, Stephanie; Dufouil, Carole; Launer, Lenore J; Kremen, William S; Longstreth, William T; Ikram, M Arfan; Seshadri, Sudha
Source
Communications Biology. 5(1)
Subject
Language
Abstract
Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P