학술논문
DNA methylation study of Huntington's disease and motor progression in patients and in animal models.
Document Type
article
Author
Lu, Ake T; Narayan, Pritika; Grant, Matthew J; Langfelder, Peter; Wang, Nan; Kwak, Seung; Wilkinson, Hilary; Chen, Richard Z; Chen, Jian; Simon Bawden, C; Rudiger, Skye R; Ciosi, Marc; Chatzi, Afroditi; Maxwell, Alastair; Hore, Timothy A; Aaronson, Jeff; Rosinski, Jim; Preiss, Alicia; Vogt, Thomas F; Coppola, Giovanni; Monckton, Darren; Snell, Russell G; William Yang, X; Horvath, Steve
Source
Nature communications. 11(1)
Subject
Language
Abstract
Although Huntington's disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EWAS) of human blood reveals that HD mutation status is significantly (p