학술논문

The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.
Document Type
article
Source
Cancer discovery. 10(7)
Subject
Humans
Pneumonia
Viral
Coronavirus Infections
Neoplasms
DNA Damage
Neoplasm Proteins
Cell Cycle
Protein Biosynthesis
Epigenomics
Drug Repositioning
Pandemics
Betacoronavirus
COVID-19
SARS-CoV-2
Pneumonia
Viral
Oncology and Carcinogenesis
Language
Abstract
The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.