학술논문
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Document Type
article
Author
Sapkota, Yadav; Steinthorsdottir, Valgerdur; Morris, Andrew P; Fassbender, Amelie; Rahmioglu, Nilufer; De Vivo, Immaculata; Buring, Julie E; Zhang, Futao; Edwards, Todd L; Jones, Sarah; O, Dorien; Peterse, Daniëlle; Rexrode, Kathryn M; Ridker, Paul M; Schork, Andrew J; MacGregor, Stuart; Martin, Nicholas G; Becker, Christian M; Adachi, Sosuke; Yoshihara, Kosuke; Enomoto, Takayuki; Takahashi, Atsushi; Kamatani, Yoichiro; Matsuda, Koichi; Kubo, Michiaki; Thorleifsson, Gudmar; Geirsson, Reynir T; Thorsteinsdottir, Unnur; Wallace, Leanne M; iPSYCH-SSI-Broad Group; Yang, Jian; Velez Edwards, Digna R; Nyegaard, Mette; Low, Siew-Kee; Zondervan, Krina T; Missmer, Stacey A; D'Hooghe, Thomas; Montgomery, Grant W; Chasman, Daniel I; Stefansson, Kari; Tung, Joyce Y; Nyholt, Dale R
Source
Nature communications. 8(1)
Subject
Language
Abstract
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P