학술논문
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Document Type
article
Author
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, ARVR; Li, Changwei; Li-Gao, Ruifang; Liu, Yongmei; Marten, Jonathan; Musani, Solomon K; Ntalla, Ioanna; Rankinen, Tuomo; Richard, Melissa; Sim, Xueling; Smith, Albert V; Tajuddin, Salman M; Tayo, Bamidele O; Vojinovic, Dina; Warren, Helen R; Xuan, Deng; Alver, Maris; Boissel, Mathilde; Chai, Jin-Fang; Chen, Xu; Christensen, Kaare; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Girotto, Giorgia; Harris, Sarah E; He, Meian; Hsu, Fang-Chi; Kühnel, Brigitte; Laguzzi, Federica; Li, Xiaoyin; Lyytikäinen, Leo-Pekka; Nolte, Ilja M; Poveda, Alaitz; Rauramaa, Rainer; Riaz, Muhammad; Rueedi, Rico; Shu, Xiao-Ou; Snieder, Harold; Sofer, Tamar; Takeuchi, Fumihiko; Verweij, Niek; Ware, Erin B; Weiss, Stefan; Yanek, Lisa R; Amin, Najaf; Arking, Dan E; Arnett, Donna K; Bergmann, Sven; Boerwinkle, Eric; Brody, Jennifer A; Broeckel, Ulrich; Brumat, Marco; Burke, Gregory; Cabrera, Claudia P; Canouil, Mickaël; Chee, Miao Li; Chen, Yii-Der Ida; Cocca, Massimiliano; Connell, John; de Silva, H Janaka; de Vries, Paul S; Eiriksdottir, Gudny; Faul, Jessica D; Fisher, Virginia; Forrester, Terrence; Fox, Ervin F; Friedlander, Yechiel; Gao, He; Gigante, Bruna; Giulianini, Franco; Gu, Chi Charles; Gu, Dongfeng; Harris, Tamara B; He, Jiang; Heikkinen, Sami; Heng, Chew-Kiat; Hunt, Steven; Ikram, M Arfan; Irvin, Marguerite R; Kähönen, Mika; Kavousi, Maryam
Source
Molecular psychiatry. 26(6)
Subject
Language
Abstract
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P