학술논문
APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).
Document Type
article
Author
Granot-Hershkovitz, Einat; Tarraf, Wassim; Kurniansyah, Nuzulul; Daviglus, Martha; Isasi, Carmen R; Kaplan, Robert; Lamar, Melissa; Perreira, Krista M; Wassertheil-Smoller, Sylvia; Stickel, Ariana; Thyagarajan, Bharat; Zeng, Donglin; Fornage, Myriam; DeCarli, Charles S; González, Hector M; Sofer, Tamar
Source
Alzheimer's & dementia : the journal of the Alzheimer's Association. 17(3)
Subject
Language
Abstract
IntroductionApolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.MethodsWe investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations.ResultsAPOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P-value = 0.03), with the strongest association in Cubans (OR = 1.46, P-value = 0.007). APOE-ε2 was associated with decreased risk of MCI (OR = 0.37, P-value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline.DiscussionResults suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.