학술논문
Genetic determinants of serum testosterone concentrations in men.
Document Type
article
Author
Ohlsson, Claes; Wallaschofski, Henri; Lunetta, Kathryn L; Stolk, Lisette; Perry, John RB; Koster, Annemarie; Petersen, Ann-Kristin; Eriksson, Joel; Lehtimäki, Terho; Huhtaniemi, Ilpo T; Hammond, Geoffrey L; Maggio, Marcello; Coviello, Andrea D; EMAS Study Group; Ferrucci, Luigi; Heier, Margit; Hofman, Albert; Holliday, Kate L; Jansson, John-Olov; Kähönen, Mika; Karasik, David; Karlsson, Magnus K; Kiel, Douglas P; Liu, Yongmei; Ljunggren, Osten; Lorentzon, Mattias; Lyytikäinen, Leo-Pekka; Meitinger, Thomas; Mellström, Dan; Melzer, David; Miljkovic, Iva; Nauck, Matthias; Nilsson, Maria; Penninx, Brenda; Pye, Stephen R; Vasan, Ramachandran S; Reincke, Martin; Rivadeneira, Fernando; Tajar, Abdelouahid; Teumer, Alexander; Uitterlinden, André G; Ulloor, Jagadish; Viikari, Jorma; Völker, Uwe; Völzke, Henry; Wichmann, H Erich; Wu, Tsung-Sheng; Zhuang, Wei Vivian; Ziv, Elad; Wu, Frederick CW; Raitakari, Olli; Eriksson, Anna; Bidlingmaier, Martin; Harris, Tamara B; Murray, Anna; de Jong, Frank H; Murabito, Joanne M; Bhasin, Shalender; Vandenput, Liesbeth; Haring, Robin
Source
PLoS genetics. 7(10)
Subject
Language
Abstract
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as