부산대학교 도서관

This study aims to examine the empirical insulinemic potential consisting of dietary and lifestyle factors and the interactive effect with the common genetic susceptibility locus rs2423279 on the risk of colorectal cancer. This case- control study was conducted with 923 patients of colorectal cancer and 1,846 controls. The empirical indices for assessing the insulinemic potential were calculated based on semi- quantitative food frequency and lifestyle questionnaires. A genetic variant of rs2423279 was genotyped. The significant effect between the empirical lifestyle index for insulin resistance (ELIR), which assesses dietary and lifestyle patterns related to insulin resistance, and C allele carriers of rs2423279 was stronger than that for homozygous T allele carriers regarding the risk of colorectal cancer (OR, 95% CI=2.50, 1.78-3.51, P for interaction=0.034). The empirical insulinemic potential for insulin resistance might have interactive effects with the rs2423279 polymorphism on the risk of colorectal cancer. The results of this study suggest the basis of the metabolic impact of the insulin response on colorectal carcinogenesis.