학술논문
Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
Document Type
Academic Journal
Author
Bourrier, A.; Carrat, F.; Colombel, J.-F.; Bouvier, A.-M.; Abitbol, V.; Marteau, P.; Cosnes, J.; Simon, T.; Peyrin-Biroulet, L.; Beaugerie, L.; Gendre, Jean-Pierre; Lémann, Marc; Hébuterne, Xavier; Cortot, Antoine; Bouhnik, Yoram; Laharie, David; Dupas, Jean Louis; Flourié, Bernard; Lerebours, Eric; Allez, Matthieu; Messing, Bernard; Cadiot, Guillaume; Soulé, Jean-Claude; Gornet, Jean-Marc; Veyrac, Michel; Duclos, Bernard; Beau, Philippe; Bourreille, Arnaud; Baumer, Philippe; Carbonnel, Franck; Heresbach, Denis; Metman, Etienne-Henry; Florent, Christian; Blain, Antoine; Faucheron, Jean-Luc; Bonaz, Bruno; Roblin, Xavier; Potier, Pascal; Boehm, Christian; Kurtz, Thierry; Lamouliatte, Hervé; Nion-Larmurier, Isabelle; Delchier, Jean-Charles; Chaussade, Stanislas; Weiss, Anne Marie; Cézard, Jean Pierre; Siproudhis, Laurent; Nahon, Stéphane; Sondag, Daniel; Jian, Raymond; Souquet, Jean-Christophe; Bord, Pierre; Coffin, Benoit; Dʼalmagne, Hélène; Delasalle, Patrick; Fournier, Régis; Cavicchi, Maryan; Souffran, Marc-Henry; Vandromme, Luc; Guedon, Claire; Seksik, Philippe; Michiels, Christophe; Renard, Pascal; Rogier, Patrice; Gouilloud, Sylvie; Rotenberg, André; Savoye, Guillaume; Thevenin, Alain; Mallet, Laurent; Brazier, Franck; Jean, Francois; Justum, Anne-Marie; Latrive, Jean-Paul; Gerbal, Jean-Luc; Pierrugues, Robert; Chardonnal, Gérard; Picon, Laurence; Reix, Nicole; Dʼaubigny, Nicolas Drouët; Uettwiller, Hervé; Mallet, Anne Courillon; Palacci, Alain; Bensaude, Raoul-Jacques; Bonniaud, Pierre; Empinet, Olivier; Nisard, Andrée; Rudelli, Alain; Tubiana, Bernard; Capelle, Philippe; Dabadie, Alain; Evard, Daniel; Julien, Pierre-Emile; Picon-Coste, Magali; Schneider, Stéphane; Goldfain, Denis; Bellanger, Jérôme; Blondelot, Jean-Pierre; Lamy, Philippe; Lemière, Sébastien; Mockly, Jean Francois; Pellat, Benoit; Gatineau-Sailliant, Gilles; Nalet, Bernard; Nancey, Stéphane; Kusielewicz, Daniel; Loison, Patrick; Popot, Jean-Michel; Merite, François; Roux, Jean-Pol; Afchain, Pauline; Blanquart, Alain; Heyries, Laurent; Reville, Marc; Viron, Dominique; Zerbib, Frank; Claviere, Christophe; Léostic, Didier; Pouderoux, Philippe; Moitry, Alain; Hagège, Hervé; Hugot, Jean-Pierre; Humeau, Benoit; Sabate, Jean-Marc; Lederman, Emmanuel; Lescut, Dominique; Luneau, Fabrice; Mesnard, Bruno; Smadja, Lionel; Steinberg, Michel; Brun, Marc; Macaigne, Gilles; Marchal, Jean Luc; Ollivier, Stéphane; Ouvry, Dominique; Perche, Jean Paul; Rambaud, Serge; Benamouzig, Robert; Cazenave, Jean Louis; Coffin, Jean-Charles; Blazquez, Martine; Lagneau, Marion; Person, Bruno; Wittersheim, Christian; Napoleon, Bertrand; Cemachovic, Israël; Iglicki, Franck; Howaizi, Mehran; Leprince, Eric; Leurent, Bruno; Morin, Thierry; Darsouni, Riad; Attar, Alain; Baron, Philippe; Breton, Anne; Gillion, Jean Marie; Guemene, Jean-Marc; Jouffre, Claude; Moreau, Xavier; Claude, Pierre; Quinton, André; Brichard, Jean Michel; Desaint, Benoit; Bouygues, Martin; Chatrenet, Philippe; Salmeron, Marcelo; Silvie, Jean; Waldner, Bruno; Emery, Yves; Moraillon, Armand; Kunkel, Daniel; Dubois, Philippe; Faure, Patrick; LʼHirondel, Christian; Labérenne, Jean-Eric; Moreau, Pierre; Pereira, Adelino; Plihon, Genevieve; Wolff, Thierry; Ngo, Yann; Boruchowicz, Arnaud; Jost, Béatrice; Gotlib, Jean Pierre; Danne, Odile; Raoux, Philippe; Ramond-Bouhali, Marie-José; Baetz, Andre; Veyres, Bruno; Chapoutot, Christian; Le Dréau, Gérard; Filippi, Jérôme; Mudry, Jean; Kalt, Philippe; Minault, Sophie; Bounin, Pierre-André; Andréani, Tony; Charneau, Jacky; Reijasse, Didier; Bolze, Jean-Louis; Thaunat, Jean Luc; Le Couteulx, Christian; Maurage, Chantal; Bader, Robert; Codjovi, Philippe; Migairou, Jean-Luc; Morali, Alain; Rey, Philippe; Molard, Bruno Richard; Petit, Richard; Koch, Stéphane; Cassan, Philippe; Deschamps, Jean-Paul; Caby, Christine Meicler; Meurisse, Jean-Jacques; Prades, Philippe; Boulant, James; Diacono, Michel; Monsch, Jean-Marie; Dupuy, J-François; Bellaiche, Guy; Guegan, Martine; Comte, Jean-Marc; Cayla, Jean-Michel; Le Tallec, Francois; Meurisse, Franck; Desurmont, Philippe; Roget, Laurent; Bouyssou, Philippe; Le Gall, Bruno; Bloch, Francis; Larvol, Loic; Jullien, Monique; Moreau, Jacques; Rebouissoux, Laurent; Decroix, Bruno; Dib, Nina; Dieterling, Paul; Lenormand, Frédéric; Lagier, Emmanuel; Fallourd, Philippe; Charpin, Serge; Bertrand, Hugues; Bommelaer, Gilles; Battistelli, Daniel; Delon, Bernard; Dentant, Lionel; Dorval, Etienne; Dumortier, Jérôme; Gaye-Bareyt, Eric; Gerosa, Yves; Guez, Chantal; Mornet, Martine; Benfredj, Paul; Piperaud, René; Stremsdoerfer, Noel; Verdier, Eric; Grinholtz, Alain; Barjonet, Georges; See, Antoine; Arotçarena, Ramuntxo; Baudet, Anne; Broyer, Joel; Charachon, Antoine; Blondon, Hugues; Mouton, Pascal; Claudez, Hubert; Labat-Labourdette, Jacques; Haëm, Jacques; Estable, Patrick; Levy, Patrick; Rosenbaum, Alain; Balavoine, Yvon; Blanchi, Alain; Coutarel, Pierre; Delaperriere, Nadege; Dervichian, Michel; Marois, Francis; Seroka, Jacques; Michaud, Laurent; Leroy, Olivier; Meyran, Emmanuel; Poilroux, Bernard; Tensaouti, Abdallah; Paupard, Thierry; Agard, Dominique; Beaulieu, Sandrine; Benfiguig, Kader; Capony, Patrice; Cottereau, Jean; Desreumaux, Pierre; Dramard, Jean-Michel; Duché, Mathieu; Mamou, Patrick; Etienney, Isabelle; DʼAbrigeon, Gilles; Godeberge, Béatrice; Tucat, Gilbert; Puech, Jean; Roger, Jean; Lapalus, Marie-George; Bauret, Paul; Houcke, Philippe; Pornin, Béatrice; Champigneulle, Bruno; Cuissard, Laurent; David, Xavier-Richard; Lombard, Frédéric; Granveau, Antoine; Hamon, Jean-François; Ink, Olivier; Blondel, Fabienne; Namias, Alain; Pillon, Didier; Reignier, Antoine; Tordjman, Gilles; Christidis, Christos; Zirabe, Simon; Audebert, Michel; Bion, Eric; Bourgeaux, Claude; Poupardin, Cécile; Deplaix, Philippe; Fratini, Gérard; Garnier, Thierry; Desseaux, Gerard; Magois, Hervé; Lochum, Sylvain; Vergier, Jean-Francois; Texereau, Patrick; Rat, Christel; Uzzan, Francoise; Vidal, Alain; Vinante, Nadia; Watrin, Bernard; Wurtz-Huckert, Cécile; Barre, Bruno; Ferbus, Dominique Chaslin; Contou, Jean-François; Coupier, Dominique; David, Benoit; Gargot, Dany; Huc, Denis; Barraya, Remy; Faroux, Roger; Fourgeaud, Jean-Luc; Grimprel, Hubert; Auroux, Jean; Rey, Jean-François; Arnoux, Jean Pierre; Lentini, Franck; Tardy, Ludovic; Mouterde, Olivier; Spyckerelle, Claire; Vacherot, Bruno; Weissman, Alain; Alpérine, Michel; Le Sidaner, Anne; Bonnet-Eymard, Pierre-Olivier; Colson, Jean Louis; Pellet, Daniel; Deltombe, Bernard; Edouard, André; Maechel, Henri; Jaillet, Jean-Claude; Genes, Julien; Leveque, Anne-Marie; Lucidarme, Damien; Maignan, Philippe; Gehrke, Nathalie Mallier; Sanchez, Jérôme; Tusseau, Frank; Casteur, Alban; Bottlaender, Jacques; Constantini, Denis; Coton, Thierry; Even, Philippe; Druart, Francois; Riot, François; Gauchet, Jean-Michel; Hecquet, Geneviève; Henry, Gerard; Hochain, Patrick; Arpurt, Jean Pierre; Medini, Abdelkrim; Dartois-Hoguin, Michele; Moindrot, Henri; Emery, Philippe; Periac, Pierre; Prunier, Annie; Renkes, Pascal; Tawil-Longreen, Christine; Vincent, Edmond; Vitte, René-Louis; Loeb, Christian; Carwana, Alain; Barbereau, Didier; Bohon, Philippe; Corrieri-Baizeau, Céline; Sahy, Daniel; Derreveaux, Philippe; David, Dominique; Desbazeille, François; Fontenelle, Patrick; Slama, Jean Luc; Le Mercier, Yvon; Certin, Michel; Reig, Jean Jacques; Rosa, Isabelle; Helbert, Thierry; Tounian, Patrick; Turner, Luc; Perot, Valéry; Aillet, Luc; Pauwels, Arnaud; Barré, Philippe; Nury, Bernard; Cazalbou, Claude; Devulder, Franck; Durget, Alain; Dubroca, Jeanne; Gaudy, Daniele; Greff, Michel; Jacques, Christian; Lafarge, Jocelyne; Kezachian, Gilles; Le Gall, Ronan; Pariente, Alex; Pinault, Tiphaine; Bismuth, Michaël; Boyer-Darrigrand, Nathalie; Bretagnolle, Philippe; Carpentier, Stephane; Cholet, Franck; Theodore, Christian; Combes, Rémi; Combet, Francois; Delanoe, Christophe; De Montigny, Stéphanie; Soudan, Denis; Fourdan, Olivier; Minier, Gilles; Languepin, Jeanne; Roche, Jean; Ginies, Jean-Louis; Nouel, Olivier; Petitgars, Philippe; Robin, Edith; Hamm, Romain; Roques, Jean François; Roussin-Bretagne, Sylvie; Sénéjoux, Agnès; Muron, Sophie; Bardoux, Nicolas; Berthelemy, Philippe; Madonia, Patrick; Carles, Bertrand; Reynier, Catherine; Cuillerier, Emmanuel; Dadamessi, Innocenti; Danis, Jacques; Debenes, Bernard; Dubuc-Rey, Nathalie; Lesur, Gilles; Jouet, Pauline; Lenaerts, Catherine; Garret, Marc; Mineur, Alexandra; Chabry, Bernard; Pigot, Francois; Rossi, Valérie; Tennenbaum, Ruth; Salloum, Julien; Slaoui, Maurice Hakim; Mathieu, Stéphane; Papapietro, Valérie; Viola, Sheila; Bezet, Alexis; Altman, Claude; Audan, Alain; Calabet, Jean; Masliah, Claude; Fayemendy, Laurent; Duruy, Marc; Gauffeny, Benoit; Helie, Ludovic; Imani, Kamran; Janin-Manificat, Raoul; Galmiche, Jean-Paul; Kerlirzin, Anne; Bedenne, Laurent; Locher, Christophe; Michaudel, Gilles; Missonnier, Gilles; Rinaldi-Dovio, Michel; Rouillon, Jean-Michel; Ecuer, Stéphane; Patenotte, Arnaud; Bronstein, Jean Ariel; Baty, Vincent; Bougnol, Michel; Bourbon, Pierre; Cerbelaud, Philippe; Chavaillon, Annick; Boiffin, Franck; Dubern, Béatrice; De Laguierce, Isabelle Duval; Greco, Fernand; Bouhot, Florence; Godeberge, Philippe; Grandmaison, Brigitte; Gros, Pascal; Targues, Guy; Corallo, Jacques; Boutin, Jean; Guillan, Jacques; Barbieux, Jean Pierre; Lariviere, Isabelle Loury; Le Genissel, Henri; Leroi, Henri; Bellaiche, Marc; Elie-Legrand, Marie-Claire; Dapoigny, Michel; Denoyel, Philippe; Pienkowski, Patrice; Pouche, Philippe; Saurfelt, Marc Michel; Thorel, Jean Marie; Piche, Thierry; Travers, Bruno; Tuvignon, Patrick; Zalcberg, Marc; Boulay, Guy; Zamora, Christophe; Samama, Joelle; Ricotie, Etienne; De Fleury, Patrice; Maille, Francois; Mougenel, Jean Louis; Gonot, Olivier; Menat, Jean Philippe; Kaassis, Mehdi; Lang, Francoise; Abramowitz, Laurent; Ganne, Nathalie; Pecriaux, Olivier; Seyrig, Jacques-Arnaud; Sobhani, Iradj; Parmentier, Thierry; Van Nieuwenhuyse, Antoine; Weber, Francois-Xavier; Glibert, André; Bineau, Catherine; Canet, Bernard; Collin, Catherine; Cordet, Frederic; Parlier, David David; Carre, Dominique; Peytier, Annie; Fein, Francine; Barouk, Jerome; Dewannieux, Jacques; Hartwig, Johannes; Jouve, Jean-Louis; Laplane, Bertrand; Lascar, Gilles; Legrand, Christophe; Le Marchand, Pierre; Liebaert, Marie Pierre; Terdiman-Pire, Michele; Abdelli, Naceur; Neveu, Dominique; De La Lande, Philippe; De Saint Louvent, Patrick; Pelatan, Cécile; Petit, Agnès; Richecoeur, Martial; Texier, Frederic; Cazals, Jean Brice; Tissot, Bertrand; Mourrut, Christian; Doubremelle, Marie; Foltz, Marc; Gautier-Jubé, Florence; Martin, Jacques; Khouri, Elie; Lons, Thierry; Carlier-Bandu, Martine; Monnin, Jean-Luc; Roche, Hervé; Willemin, Bernard; Houard, Xavier; Fatisse, Abdelaziz; le Algard, Michè; Arab, Kamel; Borel, Isabelle; Lagarrigue, Cécile; Chryssostalis, Ariane; Boutroux, Dominique; Dupuychaffray, Jean-Pierre; Khaddari, Saïd; Mion, François; Puy-Montbrun, Thierry; Girardet, Jean-Philippe; Gury, Bruno; Landau, Alain; Le Bihan, Monique; Nieuviarts, Sandrine; Ollivry, Jean; Le Bourgeois, Philippe; Piquet, Marie-Astrid; Escartin, Michel-Pierre; Systchenko, Remi; Venezia, Franck; Wantiez, Michel; Lesage, Xavier; Zrihen, Elie; Aygalenq, Philippe; Dieumegard, Barbara; Savarieau, Bernard; Bulois, Philippe; Cattan, Stéphane; Diez, Jean-Lucien; Fauchot, Olivier; Durous, Eric; Gazut, Valérie; Guilleminet, Christian; Bories, Jean-Marc; Le Floch, Isabelle Joly; Vove, Jean-Paul; Lelouch, Stéphane; Lévy, Philippe; Lhopital, François; Marcato, Norma; Mozer-Bernardeau, Marianne; Nousbaum, Jean-Baptiste; Cattan, Philippe; Plane, Alain; Raymond, Jean-Michel; Roseau, Gilles; Rozental, Gerald; Boustière, Christian; Bonny, Corinne; Cordier-Collet, Mariepierre; Courat, Laurent; Croguennec, Bernard; Delaunay-Tardy, Karine; Labarriere, Damien; Geagea, Edmond; Gottrand, Frédéric; Gelsi, Eve; Thiefin, Gerard; Wohlschies, Eric; Miguet, Mathieu; Ponsot, Philippe; Suzanne, Jean; Teste, Yves; Gossart, Anne-Claire Dupont; Baroni, Jean-Luc; Benchaa, Benabdallah; Blanc, Georges; Maroy, Bernard; Bonjean, Philippe; Brézault, Catherine; Bridoux-Henno, Laure; Chayette, Claude; Auby, Dominique; Fiorucci, Robert; Galindo, Georges; Hubert, Gilles; Bonneau, Gilles; Marinier, Evelyne; Pouteau, Michele; Alamdari, Afchine; Delbende, Bruno; Chamouard, Patrick; DʼAbravanel, Pascale; DallʼOsto, Hélène; Hervé, Sophie; Lefebvre, Jean; Levoir, Damien; Lillo, Philippe; Rouch, Michel; Mathonnet, Muriel; De Lustrac, Mercédes; Ramond, François-Jean; Roupret, Bernard; Soupison, Alain
Source
Alimentary Pharmacology & Therapeutics. Jan 01, 2016 43(2):252-261
Subject
Language
English
ISSN
0269-2813
Abstract
BACKGROUND: The risk of urinary tract cancers, including kidney and bladder cancers, was increased in transplant recipients receiving thiopurines. AIM: To assess the risk of urinary tract cancers in patients with inflammatory bowel disease (IBD) receiving thiopurines in the CESAME observational cohort. METHODS: Between May 2004 and June 2005, 19 486 patients with IBD, 30.1% of whom were receiving thiopurines, were enrolled. Median follow-up was 35 months (IQR: 29–40). RESULTS: Ten and six patients developed respectively kidney and bladder cancer. The incidence rates of urinary tract cancer were 0.48/1000 patient-years in patients receiving thiopurines (95% CI: 0.21–0.95), 0.10/1000 patient-years in patients who discontinued thiopurines (95% CI: 0.00–0.56) and 0.30/1000 patient-years in patients never treated with thiopurines (95% CI: 0.12–0.62) at entry. The standardised incidence ratio of urinary tract cancer was 3.40 (95% CI: 1.47–6.71, P = 0.006) in patients receiving thiopurines, 0.64 (95% CI: 0.01–3.56, P = 0.92) in patients previously exposed to thiopurines and 1.17 (95% CI: 0.47–12.42, P = 0.78) in patients never treated with thiopurines. The multivariate-adjusted hazard ratio (HR) of urinary tract cancer between patients receiving thiopurines and those not receiving thiopurines was 2.82 (95% CI: 1.04–7.68, P = 0.04). Other significant risk factors were male gender (HR: 3.98, 95% CI: 1.12–14.10, P = 0.03) and increasing age (HR after 65 years (ref <50): 13.26, 95% CI: 3.52–50.03, P = 0.0001). CONCLUSION: Patients with IBD receiving thiopurines have an increased risk of urinary tract cancers. Clinically relevant excess risk is observed in older men.