학술논문
Possible Effect of Chelation Treatment on Metabolomic and Lipidomic Analysis in Lead Exposure
Document Type
Academic Journal
Author
Source
Journal of Occupational and Environmental Medicine. Feb 01, 2022
Subject
Language
English
ISSN
1076-2752
Abstract
OBJECTIVE:: This study aimed to examine patients with lead poisoning in terms of metabolomic profiles and bioactive lipids (oxysterols and S1P) before and after chelation therapy. METHODS:: Consent was obtained from 42 individuals diagnosed with lead poisoning and blood and urine samples were collected before and after chelation therapy. The levels of 7-KC, C-triol and S1P were measured via LC-MS/MS. Metabolomic analysis was performed via GC-MS. RESULTS:: 7-KC and C-triol levels were detected higher before chelation therapy compared to after therapy (p < 0.001 for both). S1P levels were measured higher before the therapy. The results also showed that sphingolipid metabolism-related pathways were affected by lead toxicity as well as other related pathways. CONCLUSION:: This preliminary study showed that lipid metabolism is affected in lead exposure and chelation therapy is effective in reversing possible damage.