부산대학교 도서관

PURPOSE:: To evaluate associations between choroidal thickness and features of Polypoidal Choroidal Vasculopathy (PCV) lesions based on multimodal imaging. METHODS:: This cross-sectional analysis included treatment-naïve PCV eyes from a prospectively recruited observational cohort were included. Associations between SFCT with qualitative and quantitative morphologic features of PCV lesions on color fundus photographs, indocyanine green and fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) were evaluated. RESULTS:: We included 100 eyes with ICGA-proven PCV. SFCT showed a bimodal distribution with peaks at 170 µm and 350µm. There was a significant linear increase in total lesion area (p-trend=0.028) and polypoidal lesion area (p-trend=0.030 and p-continuous=0.037) with increasing SFCT. Pairwise comparisons between quartiles showed that the total lesion area (4.20 ± 2.61 vs 2.89 ± 1.43 mm, p=0.024) and the polypoidal lesion area (1.03 ± 1.01 vs 0.59 ± 0.45mm, p=0.042) are significantly larger in eyes in Q4 (SFCT= >350 um) than eyes in Q1 (SFCT= <170um). Whilst there was no significant linear trend relating SFCT to BCVA, pairwise comparisons showed that eyes in Q4 (SFCT ≥ 350 um) have significantly worse vision (0.85 ± 0.63 vs 0.55 ± 0.27, p=0.030) than eyes in Q2 (SFCT 170 -260um). CONCLUSIONS:: Total lesion areas and polypoidal lesion areas tend to be larger in eyes with increasing SFCT. Choroidal background may influence the phenotype or progression pattern of PCV.