부산대학교 도서관

BACKGROUND:: We hypothesized that postural instability and cognitive decline in patients with Richardsonʼs syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy-parkinsonism may be reflected by alterations in putaminal metabolism. METHODS:: Eleven patients with Richardsonʼs syndrome, 8 patients with progressive supranuclear palsy-parkinsonism, 12 with Parkinsonʼs disease, and 10 controls underwent clinical assessment and fluorodeoxyglucose positron emission tomography (PET). RESULTS:: Richardsonʼs syndrome patients showed pronounced thalamic hypometabolism, and patients with progressive supranuclear palsy-parkinsonism pronounced putaminal hypometabolism, compared to all other investigated groups. The putamen/thalamus uptake ratio differentiated progressive supranuclear palsy-parkinsonism from Richardsonʼs syndrome (area under the curve = 0.86) and from Parkinsonʼs disease (area under the curve = 0.80) with acceptable accuracy. Frontal hypometabolism was predominantly found in Richardsonʼs syndrome patients. CONCLUSIONS:: Richardsonʼs syndrome, progressive supranuclear palsy-parkinsonism and Parkinsonʼs disease showed different metabolic patterns in fluorodeoxyglucose PET. © 2011 Movement Disorder Society