학술논문
A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia
Document Type
Academic Journal
Author
Treurniet, Kilian M; Berkhemer, Olvert A; Immink, Rogier V; Lingsma, Hester F; Ward-van der Stam, Vivian M C; Hollmann, Markus W; Vuyk, Jaap; van Zwam, Wim H; van der Lugt, Aad; van Oostenbrugge, Robert J; Dippel, Diederik W J; Coutinho, Jonathan M; Roos, Yvo B W E M; Marquering, Henk A; Majoie, Charles B L M; Dippel, Diederik W J; Lugt, Aad van der; Majoie, Charles B L M; Roos, Yvo B W E M; van Oostenbrugge, Robert J; van Zwam, Wim H; Berkhemer, Olvert A; Fransen, Puck S S; Beumer, Debbie; van den Berg, Lucie A; Schonewille, Wouter J; Vos, Jan Albert; Majoie, Charles B L M; Roos, Yvo B W E M; Nederkoorn, Paul J; Wermer, Marieke J H; Walderveen, Marianne A A van; van Oostenbrugge, Robert J; van Zwam, Wim H; Staals, Julie; Hofmeijer, Jeannette; van Oostayen, Jacques A; Nijeholt, Geert J Lycklama à; Boiten, Jelis; Dippel, Diederik W J; Brouwer, Patrick A; Emmer, Bart J; de Bruijn, Sebastiaan F; van Dijk, Lukas C; Kappelle, L Jaap; Lo, Rob H; van Dijk, Ewoud J; de Vries, Joost; de Kort, Paul L M; van den Berg, Jan S P; van Rooij, Willem Jan J; van Hasselt, Boudewijn A A M; Aerden, Leo A M; Dallinga, René J; Visser, Marieke C; Bot, Joseph C J; Vroomen, Patrick C; Eshghi, Omid; Schreuder, Tobien H C M L; Heijboer, Roel J J; Keizer, Koos; Tielbeek, Alexander V; Hertog, Heleen M den; Gerrits, Dick G; van den Berg-Vos, Renske M; Karas, Giorgos B; Majoie, Charles B L M; van Zwam, Wim H; van der Lugt, Aad; Nijeholt, Geert J Lycklama à; van Walderveen, Marianne A A; Bot, Joseph C J; Marquering, Henk A; Beenen, Ludo F; Sprengers, Marieke E S; Jenniskens, Sjoerd F M; van den Berg, René; Berkhemer, Olvert A; Yoo, Albert J; Roos, Yvo B W E M; Koudstaal, Peter J; Boiten, Jelis; van Dijk, Ewoud J.; van Oostenbrugge, Robert J; Wermer, Marieke J H; Flach, H Zwenneke; Steyerberg, Ewout W; Lingsma, Hester F
Source
Journal of NeuroInterventional Surgery. Feb 01, 2018 10(2):107-111
Subject
Language
English
ISSN
1759-8478
Abstract
BACKGROUND: Up to two-thirds of patients are either dependent or dead 3 months after thrombectomy for acute ischemic stroke (AIS). Loss of cerebral autoregulation may render patients with AIS vulnerable to decreases in mean arterial pressure (MAP). OBJECTIVE: To determine whether a fall in MAP during intervention under general anesthesia (GA) affects functional outcome. METHODS: This subgroup analysis included patients from the MR CLEAN trial treated with thrombectomy under GA. The investigated variables were the difference between MAP at baseline and average MAP during GA (ΔMAP) as well as the difference between baseline MAP and the lowest MAP during GA (ΔLMAP). Their association with a shift towards better outcome on the modified Rankin Scale (mRS) after 90 days was determined using ordinal logistic regression with adjustment for prognostic baseline variables. RESULTS: Sixty of the 85 patients treated under GA in MR CLEAN had sufficient anesthetic information available for the analysis. A greater ΔMAP was associated with worse outcome (adjusted common OR (acOR) 0.95 per point mm Hg, 95% CI 0.92 to 0.99). An average MAP during GA 10 mm Hg lower than baseline MAP constituted a 1.67 times lower odds of a shift towards good outcome on the mRS. For ΔLMAP this association was not significant (acOR 0.97 per mm Hg, 95% CI 0.94 to 1.00, p=0.09). CONCLUSIONS: A decrease in MAP during intervention under GA compared with baseline is associated with worse outcome. TRIAL REGISTRATION NUMBER: NTR1804; ISRCTN10888758; post-results.