학술논문
Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes
Document Type
Academic Journal
Author
Strambo, Davide; Marto, João Pedro; Ntaios, George; Nguyen, Thanh N.; Michel, Patrik; Herzig, Roman; Członkowksa, Anna; Demeestere, Jelle; Yassin Mansour, Ossama; Georgiopoulos, Georgios; Nogueira, Raul G.; Salerno, Alexander; Wegener, Susanne; Baumgartner, Philipp; Cereda, Carlo W.; Bianco, Giovanni; Beyeler, Morin; Arnold, Marcel; Carrera, Emmanuel; Machi, Paolo; Altersberger, Valerian; Bonati, Leo; Gensicke, Henrik; Bolognese, Manuel; Peters, Nils; Wetzel, Stephan; Magriço, Marta; Nuno Ramos, João; Sargento-Freitas, João; Machado, Rita; Maia, Carolina; Machado, Egídio; Paiva-Nunes, Ana; Ferreira, Patrícia; Pinho-e-Melo, Teresa; Carvalho-Dias, Mariana; Paula, André; Alberto Correia, Manuel; Castro, Pedro; Azevedo, Elsa; Albuquerque, Luís; Nuno-Alves, José; Ferreira-Pinto, Joana; Meira, Torcato; Pereira, Liliana; Rodrigues, Miguel; Araújo, André; Rodrigues, Marta; Rocha, Mariana; Pereira-Fonseca, Ângelo; Ribeiro, Luís; Varela, Ricardo; Cappellari, Manuel; Zivelonghi, Cecilia; Sajeva, Giulia; Zini, Andrea; Gentile, Mauro; Forlivesi, Stefano; Migliaccio, Ludovica; Sessa, Maria; Pezzini, Alessandro; Sangalli, Davide; Zedde, Marialuisa; Pascarella, Rosario; Diamanti, Susanna; Beretta, Simone; Schwarz, Ghil; Frisullo, Giovanni; Marcheselli, Simona; Seners, Pierre; Sabben, Candice; Escalard, Simon; Piotin, Michel; Maier, Benjamin; Charbonnier, Guillaume; Vuillier, Fabrice; Legris, Loic; Cuisenier, Pauline; Vodret, Francesca R.; Marnat, Gaultier; Liegey, Jean-Sebastien; Sibon, Igor; Flottmann, Fabian; Broocks, Gabriel; Gloyer, Nils-Ole; Bohmann, Ferdinand O.; Hendrik Schaefer, Jan; Nolte, Christian H.; Audebert, Heinrich; Siebert, Eberhard; Sykora, Marek; Lang, Wilfried; Ferrari, Julia; Mayer-Suess, Lukas; Knoflach, Michael; Gizewski, Elke-Ruth; Stolp, Jeffrey; Stolze, Lotte J.; Coutinho, Jonathan M.; Nederkoorn, Paul J.; van-den-Wijngaard, Ido; de Meris, Joke; Lemmens, Robin; De Raedt, Sylvie; Vandervorst, Fenne; Pierre Rutgers, Matthieu; Guilmot, Antoine; Dusart, Anne; Bellante, Flavio; Calleja-Castaño, Patricia; Ostos, Fernando; Gonzalez-Ortega, Guillermo; Martín-Jiménez, Paloma; García-Madrona, Sebastian; Cruz-Culebras, Antonio; Vera, Rocio; Matute, Maria-Consuelo; Fuentes, Blanca; Alonso-de-Leciñana, María; Rigual, Ricardo; Díez-Tejedor, Exuperio; Pérez-Sánchez, Soledad; Montaner, Joan; Díaz-Otero, Fernando; Perez de la Ossa, Natalia; Flores-Pina, Belén; Muñoz-Narbona, Lucia; Chamorro, Angel; Rodríguez-Vázquez, Alejandro; Renú, Arturo; Ayo-Martin, Oscar; Hernandez-Fernandez, Francisco; Segura, Tomas; Tejada-Meza, Herbert; Hlaing, Thant; See, Isaiah; Simister, Robert; Werring, David J.; Saxhaug Kristoffersen, Espen; Nordanstig, Annika; Jood, Katarina; Rentzos, Alexandros; Šimůnek, Libor; Krajíčková, Dagmar; Krajina, Antonín; Mikulík, Robert; Cviková, Martina; Vinklárek, Jan; Školoudík, David; Roubec, Martin; Hurtikova, Eva; Hrubý, Rostislav; Ostry, Svatopluk; Skoda, Ondrej; Pernicka, Marek; Kočí, Lubomír; Eichlová, Zuzana; Jíra, Martin; Kovář, Martin; Panský, Michal; Mencl, Pavel; Paloušková, Hana; Tomek, Aleš; Janský, Petr; Olšerová, Anna; Šrámek, Martin; Havlíček, Roman; Malý, Petr; Trakal, Lukáš; Fiksa, Jan; Slovák, Matěj; Karliński, Michał; Nowak, Maciej; Sienkiewicz-Jarosz, Halina; Bochynska, Anna; Wrona, Pawel; Homa, Tomasz; Sawczynska, Katarzyna; Slowik, Agnieszka; Wlodarczyk, Ewa; Wiącek, Marcin; Tomaszewska-Lampart, Izabella; Sieczkowski, Bartosz; Bartosik-Psujek, Halina; Bilik, Marta; Bandzarewicz, Anna; Dorobek, Malgorzata; Zielińska-Turek, Justyna; Nowakowska-Kotas, Marta; Obara, Krystian; Urbanowski, Paweł; Budrewicz, Sławomir; Guziński, Maciej; Świtońska, Milena; Rutkowska, Iwona; Sobieszak-Skura, Paulina; Łabuz-Roszak, Beata; Dębiec, Aleksander; Staszewski, Jacek; Stępień, Adam; Zwiernik, Jacek; Wasilewski, Grzegorz; Tiu, Cristina; Terecoasă, Elena-Oana; Radu, Razvan-Alexandru; Negrila, Anca; Dorobat, Bogdan; Panea, Cristina; Tiu, Vlad; Petrescu, Simona; Özcan-Özdemir, Atilla; Mahmoud, Mostafa; El-Samahy, Hussam; Abdelkhalek, Hazem; Al-Hashel, Jasem; Ibrahim Ismail, Ismail; Salmeen, Athari; Ghoreishi, Abdoreza; Sabetay, Sergiu; Gross, Hana; Klein, Piers; Abdalkader, Mohamad; Jabbour, Pascal; El Naamani, Kareem; Tjoumakaris, Stavropoula; Abbas, Rawad; Mohamed, Ghada-A.; Chebl, Alex; Min, Jiangyong; Hovingh, Majesta; Tsai, Jenny; Khan, Muhib-A.; Nalleballe, Krishna; Onteddu, Sanjeeva; Masoud, Hesham E.; Michael, Mina; Kaur, Navreet; Maali, Laith; Abraham, Michael; Khandelwal, Priyank; Bach, Ivo; Ong, Melody; Babici, Denis; Khawaja, Ayaz-M.; Hakemi, Maryam; Rajamani, Kumar; Cano-Nigenda, Vanessa; Arauz, Antonio; Amaya, Pablo; Llanos, Natalia; Arango, Akemi; Vences, Miguel A.; Barrientos, José-Domingo; Caetano, Rayllene; Targa, Rodrigo; Scollo, Sergio; Yalung, Patrick; Nagendra, Shashank; Gaikwad, Abhijit; Seo, Kwon-Duk
Source
Stroke. Jan 01, 2024 55(1):78-88
Subject
Language
English
ISSN
0039-2499
Abstract
BACKGROUND:: The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcomes of revascularization treatments in patients with AIS with asymptomatic COVID-19 (AS-COVID) or symptomatic COVID-19 (S-COVID). METHODS:: We conducted an international multicenter retrospective cohort study of consecutive AIS tested for SARS-CoV-2, receiving intravenous thrombolysis and endovascular treatment between 2020 and 2021. We compared COVID-negative controls, AS-COVID, and S-COVID using multivariable regression. We assessed symptomatic intracranial hemorrhage (symptomatic intracerebral hemorrhage), mortality, and 3-month disability (modified Rankin Scale score). RESULTS:: Among 15 124 patients from 105 centers (median age, 71 years; 49% men; 39% treated with intravenous thrombolysis only; and 61% with endovascular treatment±intravenous thrombolysis), 849 (5.6%) had COVID-19, of whom 395 (46%) were asymptomatic and 454 (54%) symptomatic. Compared with controls, both patients with AS-COVID and S-COVID had higher symptomatic intracerebral hemorrhage rates (COVID-controls, 5%; AS-COVID, 7.6%; S-COVID, 9.4%; adjusted odds ratio [aOR], 1.43 [95% CI, 1.03–1.99]; aOR, 1.63 [95% CI, 1.14–2.32], respectively). Only in patients with symptomatic infections, we observed a significant increase in mortality at 24 hours (COVID-controls, 1.3%; S-COVID, 4.8%; aOR, 2.97 [95% CI, 1.76–5.03]) and 3 months (COVID-controls, 19.5%; S-COVID, 40%; aOR, 2.64 [95% CI, 2.06–3.37]). Patients with COVID-19 had worse 3-month disability regardless of disease symptoms although disability was affected to a greater extent in symptomatic patients (aOR for worse modified Rankin Scale score shift: AS-COVID, 1.25 [95% CI, 1.03–1.51]; S-COVID, 2.10 [95% CI, 1.75–2.53]). S-COVID had lower successful recanalization (74.9% versus 85.6%; P<0.001), first pass recanalization (20.3% versus 28.3%; P=0.005), and a higher number of passes. CONCLUSIONS:: In AIS undergoing revascularization treatments, both AS-COVID and S-COVID influence the risk of intracranial bleeding and worse clinical outcomes. The magnitude of this effect is more pronounced in symptomatic infections, which also present less favorable recanalization outcomes. These findings emphasize the impact of SARS-CoV-2 infection on the prognosis of revascularized AIS independent of symptom status. REGISTRATION:: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04895462.