학술논문
Proteinuria in Children Infected with the Human Immunodeficiency Virus
Document Type
Academic Journal
Author
Source
The Journal of Pediatrics. Jun 01, 2008 152(6):844-849
Subject
Language
English
ISSN
0022-3476
Abstract
OBJECTIVES: STUDY DESIGN: RESULTS: Ninety-four (33%) had proteinuria at baseline. Of these, 32 (11.2%) had nephrotic range proteinuria (Upr/cr ≥ 1.0). Initial screening was at 11 ± 0.3 years of age, with an average follow-up of 5.6 ± 0.1 years. The mortality rate was significantly greater in those with proteinuria. During the period of observation, 15 patients with nephrotic proteinuria died or had development of end-stage renal disease, and 16 showed improvement. Of those with intermediate range proteinuria (Upr/cr ≥ 0.2 < 1.0), 3 progressed to nephrotic range proteinuria, and 39 (63%) showed resolution of the proteinuria (Upr/cr < 0.2). Improvement in proteinuria was correlated with decreasing viral load (r = 0.5; P < .01). CONCLUSIONS