학술논문
Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study
Document Type
Academic Journal
Author
Marijon, Eloi; Leclercq, Christophe; Narayanan, Kumar; Boveda, Serge; Klug, Didier; Lacaze-Gadonneix, Jonathan; Defaye, Pascal; Jacob, Sophie; Piot, Olivier; Deharo, Jean-Claude; Perier, Marie-Cecile; Mulak, Genevieve; Hermida, Jean-Sylvain; Milliez, Paul; Gras, Daniel; Cesari, Olivier; Hidden-Lucet, Françoise; Anselme, Frederic; Chevalier, Philippe; Maury, Philippe; Sadoul, Nicolas; Bordachar, Pierre; Cazeau, Serge; Chauvin, Michel; Empana, Jean-Philippe; Jouven, Xavier; Daubert, Jean-Claude; Le Heuzey, Jean-Yves; Le Heuzey, Jean-Yves; Cauchemez, Bruno; Khemache, Alain; Thomas, Olivier; Hermida, Jean-Sylvain; Kubala, Mathieu; Mathiron, Armelle; Traullé, Sarah; Dupuis, Jean-Marc; Foucault, Anthony; Tassin, Aude; Algalarrondo, Vincent; Dinanian, Sylvie; Juin, Christophe; Sebag, Claude; Briand, Florent; Guignier, Alexandre; Janin, Sébastien; Champ-Rigot, Laure; Gomes, Sophie; Milliez, Paul; Pellissier, Arnaud; Scanu, Patrice; Barthez, Olivier; Bertaux-Cattarossi, Géraldine; Duvernay-Debin, Régine; Farnier, Fabien; Laurent, Gabriel; Martel-Bourcier, Alexandra; Defaye, Pascal; Jacon, Peggy; Durand, Cyril; Durand-Dubief, Alexis; Monsarrat, Nicolas; Poty, Hervé; Boulé, Stéphane; Brigadeau, François; Fossati, Frédéric; Guédon-Moreau, Laurence; Jarwe, Mustapha; Kacet, Salem; Klug, Didier; Kouakam, Claude; Lacroix, Dominique; Marquie, Christelle; Blanc, Patrick; Echahidi, Najmeddine; Espaliat, Eric; Guy-Moyat, Benoit; Lesage, Jérôme; Deharo, Jean-Claude; Franceschi, Frédéric; Prévot, Sébastien; Aliot, Etienne; Andronache, Marius; Brembillat Perrot, Béatrice; de Chillou, Christian; Sadoul, Nicolas; Badenco, Nicolas; Chastre, Thomas; Duthoit, Guillaume; Frank, Robert; Gandjbakhch, Estelle; Gartenlaub, Olivier; Hidden-Lucet, Françoise; Himbert, Caroline; Waintraub, Xavier; Zerah, Thierry; Bauley, Karine; Chabert, Jean-Pierre; Deschildre, Alain; Lesaffre, François; Martin, Angéline; Rio, Colette; Daubert, Jean-Claude; Leclercq, Christophe; Mabo, Philippe; Pavin, Dominique; Anselme, Fréderic; Godin, Bénédicte; Savouré, Arnaud; Bisch, Laurence; Da Costa, Antoine; Romeyer, Cécile; Bakou Boula, Babe; Bronner, François; Chauvin, Michel; Douchet, Marie-Pierre; Jesel, Laurence; Marzak, Halim; Schatz, Alexandre; Cardin, Christelle; Chilon, Talia; Delay, Marc; Duparc, Alexandre; Garderes-Rollin, Anne; Maury, Philippe; Mondoly, Pierre; Somody, Elisabeth; Thomson, Emile; Chevalier, Philippe; Dulac, Arnaud; Mlotek, Marcin; Nonin-Babary, Emilie; Jouven, Xavier; Lavergne, Thomas; Le Heuzey, Jean-Yves; Marijon, Eloi; Otmani, Akli; Burban, Marc; Cebron, Jean-Pierre; Gras, Daniel; Barraud, Pascal; Langlade, Stéphane; Lipiecki, Janusz; Philippot, François; Richard, Alain; Robin, Isabelle; Schandrin, Christian; Vacher, Dominique; Cardin, Christelle; Reza Rezaei, Mohammed; Rumeau, Philippe; Fouché, Renaud; Fromentin, Stéphane; Khattar, Pierre; Le Potier, Jacques; Mouhid, Jamal; Palud, Laurent; Andres, Henri; Boureux, Christian; Chopat, Patrick; Nadji, Georges; Sultan, Pierre; Targosz, Frédéric; Doazan, Jean-Philippe; El Hajjaji, Nourédine; Hannachi, Sofiene; Noblemaire, Romain; Somody, Elisabeth; Copie, Xavier; Lascault, Gilles; Paziaud, Olivier; Piot, Olivier; Billon, Olivier; Gully, Claude; Haddad, Georges; Lipp, Damien; Mouhoub, Driss; Bru, Paul; Duplantier-Duchêne, Cécile; Milhem, Antoine; Bertrand, Julien; Boursier, Michel; Khalife, Khalifé; Zannad, Noura; Zanutto, Aude; Cuvelier, Estelle; Donfafk, Cécile; Graux, Pierre; Guiot, Aurélie; Guyomar, Yves; Heuls, Sébastien; Kallumannil, John; Semichon, Marc; Gal, Benjamin; Lopez, Michel; Pineau, Julien; Dreyfus, Xavier; Hammer, Laure; Petit, Luc; Harle, Xavier; Laborderie, Julien; Albenque, Jean-Paul; Boveda, Serge; Combes, Nicolas; Combes, Stéphane; Goutner, Christophe; Césari, Olivier; Chenevez, Patrick; Loose, Christophe; Peycher, Patrick; Durand, Cyril; Durand-Dubief, Alexis; Poty, Hervé; Alonso, Christine; Cazeau, Serge; Grimard, Caroline; Jauvert, Gael; Lazarus, Arnaud
Source
European Heart Journal. Nov 01, 2015 36(41):2767-2776
Subject
Language
English
ISSN
0195-668X
Abstract
AIMS: The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily clinical practice. METHODS AND RESULTS: A total of 1705 consecutive patients implanted with a CRT (CRT-P: 535 and CRT-D: 1170) between 2008 and 2010 were enrolled in CeRtiTuDe, a multicentric prospective follow-up cohort study, with specific adjudication for causes of death at 2 years. Patients with CRT-P compared with CRT-D were older (P < 0.0001), less often male (P < 0.0001), more symptomatic (P = 0.0005), with less coronary artery disease (P = 0.003), wider QRS (P = 0.002), more atrial fibrillation (P < 0.0001), and more co-morbidities (P = 0.04). At 2-year follow-up, the annual overall mortality rate was 83.80 [95% confidence interval (CI) 73.41–94.19] per 1000 person-years. The crude mortality rate among CRT-P patients was double compared with CRT-D (relative risk 2.01, 95% CI 1.56–2.58). In a Cox proportional hazards regression analysis, CRT-P remained associated with increased mortality (hazard ratio 1.54, 95% CI 1.07–2.21, P = 0.0209), although other potential confounders may persist. By cause-of-death analysis, 95% of the excess mortality among CRT-P subjects was related to an increase in non-sudden death. CONCLUSION: When compared with CRT-D patients, excess mortality in CRT-P recipients was mainly due to non-sudden death. Our findings suggest that CRT-P patients, as currently selected in routine clinical practice, would not potentially benefit with the addition of a defibrillator.