부산대학교 도서관

Background: The absolute and relative contribution of congenital heart disease (CHD) to mortality and morbidity varies by Socio-Demographic Index (SDI) region. Location-specific data is crucial to inform investment in resources in global CHD care.Methods: The Institute for Health Metrics and Evaluation provides estimates of fatal and non-fatal CHD from 195 countries for inclusion in epidemiologic models. Using the Global Burden of Disease - Compare visualization tool we compared mortality of CHD to other common diseases in infants 1 month to 1 year of age in SDI regions.Results: Annual global infant CHD mortality is estimated to be 95,757 (95% CI 82,496-111,344). The leading causes of death in this age group are communicable diseases in low and middle SDI countries; congenital anomalies, SIDS, non-communicable diseases and injuries in high SDI countries (Figure 1). From 1990 to 2015 the death rate from CHD was unchanged in low SDI regions (120/100,000 to 112/100,000). The death rate dropped by more than 50% for lower respiratory infections, malaria, diarrhea, and protein malnutrition, resulting in CHD going from the 9 to 5 leading cause of death. Death rates dropped in middle (126 to 80/100,00), and high (62 to 25/100/000) SDI countries; yet CHD is the number 2 and 1 cause of death, respectively, in 2015. Despite a higher absolute death rate, CHD accounts for a lower proportion of deaths in low (3%) compared to middle (12%) and high (15%) SDI countries (Figure 2).Conclusion: High CHD infant mortality, increased cause of death rank from CHD, and falling death rates from communicable and nutritional diseases in low and middle SDI regions justifies increased investment in global CHD care.