학술논문
Stroke Caused by Human Immunodeficiency Virus–Associated Intracranial Large-Vessel Aneurysmal Vasculopathy
Document Type
Academic Journal
Source
Archives of Neurology. Nov 01, 2006 63(11):1640-1642
Subject
Language
English
ISSN
0003-9942
Abstract
BACKGROUND: Intracranial aneurysms related to human immunodeficiency virus (HIV) infection have been well described in pediatric patients but not in adults. OBJECTIVE: To describe a case of intracranial large-vessel aneurysmal vasculopathy causing stroke in a 27-year-old HIV-infected woman. DESIGN: Comparison of clinical and histological data with previously published cases. SETTING: A referral hospital stroke unit. PATIENT: A 27-year-old HIV-infected woman presenting with stroke; neuroimaging demonstrated fusiform aneurysmal dilation of the left internal carotid and the left middle cerebral artery and its branches. RESULTS: Autopsy showed degeneration of the elastic lamina, myxoid degeneration, and medial atrophy, causing consequent ectasia of the involved intracranial vessels. CONCLUSION: Aneurysmal dilation of the intracranial arteries occurs in HIV-infected adults, but the pathogenic role of HIV remains unknown.