학술논문
Is Delaying a Coloanal Anastomosis the Ideal Solution for Rectal Surgery?: Analysis of a Multicentric Cohort of 564 Patients From the GRECCAR
Document Type
Academic Journal
Author
Collard, Maxime K.; Rullier, Eric; Tuech, Jean-Jacques; Sabbagh, Charles; Souadka, Amine; Loriau, Jérome; Faucheron, Jean-Luc; Benoist, Stéphane; Dubois, Anne; Dumont, Frédéric; Germain, Adeline; Manceau, Gilles; Marchal, Frédéric; Sourrouille, Isabelle; Lakkis, Zaher; Lelong, Bernard; Derieux, Simon; Piessen, Guillaume; Laforest, Anaïs; Venara, Aurélien; Prudhomme, Michel; Brigand, Cécile; Duchalais, Emilie; Ouaissi, Mehdi; Lebreton, Gil; Rouanet, Philippe; Mège, Diane; Pautrat, Karine; Reynolds, Ian S.; Pocard, Marc; Parc, Yann; Denost, Quentin; Lefevre, Jérémie H.
Source
Annals of Surgery. Nov 01, 2023 278(5):781-789
Subject
Language
English
ISSN
0003-4932
Abstract
OBJECTIVES:: To assess the specific results of delayed coloanal anastomosis (DCAA) in light of its 2 main indications. BACKGROUND:: DCAA can be proposed either immediately after a low anterior resection (primary DCAA) or after the failure of a primary pelvic surgery as a salvage procedure (salvage DCAA). METHODS:: All patients who underwent DCAA intervention at 30 GRECCAR-affiliated hospitals between 2010 and 2021 were retrospectively included. RESULTS:: Five hundred sixty-four patients (male: 63%; median age: 62 years; interquartile range: 53–69) underwent a DCAA: 66% for primary DCAA and 34% for salvage DCAA. Overall morbidity, major morbidity, and mortality were 57%, 30%, and 1.1%, respectively, without any significant differences between primary DCAA and salvage DCAA (P = 0.933; P = 0.238, and P = 0.410, respectively). Anastomotic leakage was more frequent after salvage DCAA (23%) than after primary DCAA (15%), (P = 0.016).Fifty-five patients (10%) developed necrosis of the intra-abdominal colon. In multivariate analysis, intra-abdominal colon necrosis was significantly associated with male sex [odds ratio (OR) = 2.67 95% CI: 1.22–6.49; P= 0.020], body mass index >25 (OR = 2.78 95% CI: 1.37–6.00; P = 0.006), and peripheral artery disease (OR = 4.68 95% CI: 1.12–19.1; P = 0.030). The occurrence of this complication was similar between primary DCAA (11%) and salvage DCAA (8%), (P = 0.289).Preservation of bowel continuity was reached 3 years after DCAA in 74% of the cohort (primary DCAA: 77% vs salvage DCAA: 68%, P = 0.031). Among patients with a DCAA mannered without diverting stoma, 75% (301/403) have never required a stoma at the last follow-up. CONCLUSIONS:: DCAA makes it possible to definitively avoid a stoma in 75% of patients when mannered initially without a stoma and to save bowel continuity in 68% of the patients in the setting of failure of primary pelvic surgery.