학술논문
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort
Document Type
Academic Journal
Author
Greijdanus, Nynke G.; Wienholts, Kiedo; Ubels, Sander; Talboom, Kevin; Hannink, Gerjon; Wolthuis, Albert; de Lacy, Francisco B.; Lefevre, Jérémie H.; Solomon, Michael; Frasson, Matteo; Rotholtz, Nicolas; Denost, Quentin; Perez, Rodrigo O.; Konishi, Tsuyoshi; Panis, Yves; Rutegård, Martin; Hompes, Roel; Rosman, Camiel; van Workum, Frans; Tanis, Pieter J.; de Wilt, Johannes H.W.; Bremers, Andreas J.A.; Ferenschild, Floris T.; de Vriendt, Stefanie; D’Hoore, André; Bislenghi, Gabriele; Farguell, Jordi; Lacy, Antonio M.; Atienza, Paula González; van Kessel, Charlotte S.; Parc, Yann; Voron, Thibault; Collard, Maxime K.; Muriel, Jorge Sancho; Cholewa, Hannia; Mattioni, Laura A.; Frontali, Alice; Polle, Sebastiaan W.; Polat, Fatih; Obihara, Ndidi J.; Vailati, Bruna B.; Kusters, Miranda; Tuynmann, Jurriaan B.; Hazen, Sanne J.A.; Grüter, Alexander A.J.; Amano, Takahiro; Fujiwara, Hajime; Salomon, Mario; Ruiz, Hernán; Gonzalez, Ricardo; Estefanía, Diego; Avellaneda, Nicolas; Carrie, Augusto; Santillan, Mateo; Pantoja Pachajoa, Diana A.; Parodi, Matias; Gielis, Manuel; Binder, Alf-Dorian; Gürtler, Thomas; Riedl, Peter; Badiani, Sarit; Berney, Christophe; Morgan, Matthew; Hollington, Paul; da Silva, Nigel; Nair, Gavin; Ho, Yiu M.; Lamparelli, Michael; Kapadia, Raj; Kroon, Hidde M.; Dudi-Venkata, Nagendra N.; Liu, Jianliang; Sammour, Tarik; Flamey, Nicolas; Pattyn, Paul; Chaoui, Ahmed; Vansteenbrugge, Louis; van den Broek, Nathalie E.J.; Vanclooster, Patrick; de Gheldere, Charles; Pletinckx, Pieter; Defoort, Barbara; Dewulf, Maxime; Slavchev, Mihail; Belev, Nikolay; Atanasov, Boyko; Krastev, Panche; Sokolov, Manol; Maslyankov, Svilen; Gribnev, Petar; Pavlov, Vasil; Ivanov, Tsvetomir; Karamanliev, Martin; Filipov, Emil; Tonchev, Pencho; Aigner, Felix; Mitteregger, Martin; Allmer, Caterina; Seitinger, Gerald; Colucci, Nicola; Buchs, Nicolas; Ris, Frédéric; Toso, Christian; Gialamas, Eleftherios; Vuagniaux, Aurélie; Chautems, Roland; Sauvain, Marc-Olivier; Daester, Silvio; von Flüe, Markus; Guenin, Marc-Olivier; Taha-Mehlitz, Stephanie; Hess, Gabriel F.; Martínek, Lubomír; Skrovina, Matej; Machackova, Maria; Benčurik, Vladimir; Uluk, Deniz; Pratschke, Johann; Dittrich, Luca S.; Guel-Klein, Safak; Perez, Daniel; Grass, Julia-Kristin; Melling, Nathaniel; Mueller, Simone; Iversen, Lene H.; Eriksen, Jacob D.; Baatrup, Gunnar; Al-Najami, Issam; Bjørsum-Meyer, Thomas; Teras, Jüri; Teras, Roland M.; Monib, Fatma A.; Abu Elnga Ahmed, Nagm Eldin; Alkady, Eithar; Ali, Ahmed K.; Khedr, Gehan Abd Elatti; Abdelaal, Ahmed Samir; Bassyouni Ashoush, Fouad M.; Ewedah, Moataz; Elshennawy, Eslam M.; Hussein, Mohamed; Fernández-Martínez, Daniel; García-Flórez, Luis J.; Fernández-Hevia, María; Suárez-Sánchez, Aida; del Hoyo Aretxabala, Izaskun; Docampo, Iria Losada; Zabala, Jesús Gómez; Tejedor, Patricia; Morales Bernaldo de Quirós, Javier T.; Quiroga, Ignacio Bodega; Navarro-Sánchez, Antonio; Darias, Iván Soto; Fernández, Cristina López; de La Cruz Cuadrado, Cristina; Sánchez-Guillén, Luis; López-Rodríguez-Arias, Francisco; Soler-Silva, Álvaro; Arroyo, Antonio; Bernal-Sprekelsen, Juan C.; Gómez-Abril, Segundo Á.; Gonzálvez, Paula; Torres, María T.; Sánchez, Teresa Rubio; Antona, Francisco Blanco; Sánchez Lara, Juan E.; Alcázar Montero, José A.; Fernández-Martínez, Daniel; García-Flórez, Luis J.; Fernández-Hevia, María; Suárez-Sánchez, Aida; Colás-Ruiz, Enrique; Tasende-Presedo, Marta M.; Fernández-Hurtado, Ignacio; Cifuentes-Ródenas, José A.; Suárez, Marta Castro; Losada, Manuel; Hernández, Miguel; Alonso, Alfredo; Diéguez, Beatriz; Serralta, Daniel; Medina Quintana, Rita E.; Gil Lopez, Jose M.; Pinto, Francisca Lima; Nieto-Moreno, Elena; Bonito, Alba Correa; Santacruz, Carlos Cerdán; Marcos, Elena Bermejo; Septiem, Javier García; Calero-Lillo, Aránzazu; Alanez-Saavedra, Javier; Muñoz-Collado, Salvador; López-Lara, Manuel; Martínez, María Labalde; Herrero, Eduardo Ferrero; Borda, Francisco Javier García; Villar, Óscar García; Escartín, Jorge; Blas, Juan L.; Ferrer, Rocío; Egea, Jorge García; Rodríguez-Infante, Antonio; Mínguez-Ruiz, Germán; Carreño-Villarreal, Guillermo; Pire-Abaitua, Gerardo; Dziakova, Jana; Rodríguez, Carlos Sáez-Cazallas; Pizarro Aranda, María J.; Muguerza Huguet, José M.; Borda-Arrizabalaga, Nerea; Enriquez-Navascués, José M.; Echaniz, Garazi Elorza; Ansorena, Yolanda Saralegui; Estaire-Gómez, Mercedes; Martínez-Pinedo, Carlos; Barbero-Valenzuela, Alejandro; Ruíz-García, Pablo; Kraft, Miquel; Gómez-Jurado, María J.; Pellino, Gianluca; Espín-Basany, Eloy; Cotte, Eddy; Panel, Nathalie; Goutard, Claire-Angéline; deÁngelis, Nicola; Lauka, Lelde; Shaikh, Shafaque; Osborne, Laura; Ramsay, George; Nichita, Vladimir-Ion; Bhandari, Santosh; Sarmah, Panchali; Bethune, Rob M.; Pringle, Heather C.M.; Massey, Lisa; Fowler, George E.; Hamid, Hytham K.S.; de Simone, Belinda D.; Kynaston, James; Bradley, Nicholas; Stienstra, Roxane M.; Gurjar, Shashank; Mukherjee, Tanmoy; Chandio, Ashfaq; Ahmed, Safia; Singh, Baljit; Runau, Francois; Chaudhri, Sanjay; Siaw, Oliver; Sarveswaran, Janahan; Miu, Victor; Ashmore, Daniel; Darwich, Haitham; Singh-Ranger, Deepak; Singh, Nirbhaibir; Shaban, Mohamed; Gareb, Fahed; Petropolou, Thalia; Polydorou, Adreas; Dattani, Mit; Afzal, Asma; Bavikatte, Akshay; Sebastian, Boby; Ward, Nicholas; Mishra, Amitabh; Manatakis, Dimitrios; Agalianos, Christos; Tasis, Nikolaos; Antonopoulou, Maria-Ioanna; Karavokyros, Ioannis; Charalabopoulos, Alexandros; Schizas, Dimitrios; Baili, Efstratia; Syllaios, Athanasios; Karydakis, Lysandros; Vailas, Michail; Balalis, Dimitrios; Korkolis, Dimitrios; Plastiras, Aris; Rompou, Aliki; Xenaki, Sofia; Xynos, Evangelos; Chrysos, Emmanuel; Venianaki, Maria; Christodoulidis, Grigorios; Perivoliotis, Konstantinos; Tzovaras, George; Baloyiannis, Ioannis; Ho, Man-Fung; Ng, Simon Siu-man; Mak, Tony Wing-chung; Futaba, Kaori; Šantak, Goran; Šimleša, Damir; osić, Jurica; Zukanović, Goran; Kelly, Michael E.; Larkin, John O.; McCormick, Paul H.; Mehigan, Brian J.; Connelly, Tara M.; Neary, Peter; Ryan, Jessica; McCullough, Peter; Al-Juaifari, Maytham A.; Hammoodi, Hayder; Abbood, Ali Hashim; Calabrò, Marcello; Muratore, Andrea; Terra, Antonio La; Farnesi, Francesca; Feo, Carlo V.; Fabbri, Nicolò; Pesce, Antonio; Fazzin, Marta; Roscio, Francesco; Clerici, Federico; Lucchi, Andrea; Vittori, Laura; Agostinelli, Laura; Ripoli, Maria Cristina; Sambucci, Daniele; Porta, Andrea; Sinibaldi, Giovanni; Crescentini, Giacomo; larcinese, Antonella; Picone, Emanuele; Persiani, Roberto; Biondi, Alberto; Pezzuto, Roberto; Lorenzon, Laura; Rizzo, Gianluca; Coco, Claudio; D’Agostino, Luca; Spinelli, Antonino; Sacchi, Matteo M.; Carvello, Michele; Foppa, Caterina; Spinelli, Antonino; Sacchi, Matteo M.; Carvello, Michele; Foppa, Caterina; Maroli, Annalisa; Palini, Gian M.; Garulli, Gianluca; Zanini, Nicola; Delrio, Paolo; Rega, Daniela; Carbone, Fabio; Aversano, Alessia; Pirozzolo, Giovanni; Recordare, Alfonso; DʼAlimonte, Lucrezia; Vignotto, Chiara; Corbellini, Carlo; Sampietro, Gianluca M.; Lorusso, Leonardo; Manzo, Carlo A.; Ghignone, Federico; Ugolini, Giampaolo; Montroni, Isacco; Pasini, Franceso; Pasini, Francesco; Ballabio, Michele; Bisagni, Pietro; Armao, Francesca T.; Longhi, Marco; Ghazouani, Omar; Galleano, Raffaele; Tamini, Nicolò; Oldani, Massimo; Nespoli, Luca; Picciariello, Arcangelo; Altomare, Donato F.; Tomasicchio, Giovanni; Lantone, Giuliano; Catena, Fausto; Giuffrida, Mario; Annicchiarico, Alfredo; Perrone, Gennaro; Grossi, Ugo; Santoro, Giulio A.; Zanus, Giacomo; Iacomino, Alessandro; Novello, Simone; Passuello, Nicola; Zucchella, Martino; Puca, Lucia; deGiuli, Maurizio; Reddavid, Rossella; Scabini, Stefano; Aprile, Alessandra; Soriero, Domenico; Fioravanti, Emanuela; Rottoli, Matteo; Romano, Angela; Tanzanu, Marta; Belvedere, Angela; Mariani, Nicolò M.; Ceretti, Andrea P.; Opocher, Enrico; Gallo, Gaetano; Sammarco, Giuseppe; de Paola, Gilda; Pucciarelli, Salvatore; Marchegiani, Francesco; Spolverato, Gaya; Buzzi, Gianluca; Di Saverio, Salomone; Meroni, Paola; Parise, Cristiano; Bottazzoli, Elisa I.; Lapolla, Pierfrancesco; Brachini, Gioia; Cirillo, Bruno; Mingoli, Andrea; Sica, Giuseppe; Siragusa, Leandro; Bellato, Vittoria; Cerbo, Daniele; de Pasqual, Carlo A.; de Manzoni, Giovanni; di Cosmo, Maria A.; Alrayes, Bourhan M.H.; Qandeel, Mahmoud W. M.; Hani, Mohammad Bani; Rabadi, Alexander; el Muhtaseb, Mohammad S.; Abdeen, Basel; Karmi, Fahed; Žilinskas, Justas; Latkauskas, Tadas; Tamelis, Algimantas; Pikūnienė, Ingrida; Šlenfuktas, Vygintas; Poskus, Tomas; Kryzauskas, Marius; Jakubauskas, Matas; Mikalauskas, Saulius; Jakubauskiene, Lina; Hassan, Soha Y.; Altrabulsi, Amani; Abdulwahed, Eman; Ghmagh, Reem; Deeknah, Abdulqudus; Alshareea, Entisar; Elhadi, Muhammed; Abujamra, Saleh; Msherghi, Ahmed A.; Tababa, Osama W.E.; Majbar, Mohammed A.; Souadka, Amine; Benkabbou, Amine; Mohsine, Raouf; Echiguer, Sabrillah; Moctezuma-Velázquez, Paulina; Salgado-Nesme, Noel; Vergara-Fernández, Omar; Sainz-Hernández, Juan C.; Alvarez-Bautista, Francisco E.; Zakaria, Andee D.; Zakaria, Zaidi; Wong, Michael P.K.; Ismail, Razif; Ibrahim, Aini F.; Abdullah, Nik A.N.; Julaihi, Rokayah; Bhat, Sameer; OʼGrady, Greg; Bissett, Ian; Lamme, Bas; Musters, Gijsbert D.; Dinaux, Anne M.; Grotenhuis, Brechtje A.; Steller Arend G.J. Aalbers, Ernst J.; Leeuwenburgh, Marjolein M.; Rutten, Harm J.T.; Burger, Jacobus W.A.; Bloemen, Johanne G.; Ketelaers, Stijn H.J.; Waqar, Usama; Chawla, Tabish; Rauf, Hareem; Rani, Pallavi; Talsma, Aaldert K.; Scheurink, Lieke; van Praagh, Jasper B.; Segelman, Josefin; Nygren, Jonas; Anderin, Kajsa; Tiefenthal, Marit; de Andrés, Beatriz; Beltrán de Heredia, Juan P.; Vázquez, Andrea; Gómez, Tania; Golshani, Parisa; Kader, Rawaz; Mohamed, Abudi; Westerterp, Marinke; Marinelli, Andreas; Niemer, Quirine; Doornebosch, Pascal G.; Shapiro, Joël; Vermaas, Maarten; de Graaf, Eelco J.R.; van Westreenen, Hendrik L.; Zwakman, Marije; van Dalsen, Annette D.; Vles, Wouter J.; Nonner, Joost; Toorenvliet, Boudewijn R.; Janssen, Paul T.J.; Verdaasdonk, Emiel G.G.; Amelung, Femke J.; Peeters Renu R. Bahadoer, Koen C.M.J.; Holman, Fabian A.; Heemskerk, Jeroen; Vosbeek, Noortje; Leijtens, Jeroen W.A.; Taverne, Sophie B.M.; Heijnen, Bob H.M.; El-Massoudi, Youssef; de Groot-van Veen, Irene; Hoff, Christiaan; Jou-Valencia, Daniela; Consten, Esther C.J.; Burghgraef, Thijs A.; Geitenbeek, Ritch; Hulshof, Lorenzo G.W.L.; Slooter, Gerrit D.; Reudink, Muriël; Bouvy, Nicole D.; Wildeboer, Aurelia C. L.; Verstappen, Sonja; Pennings, Alexander J.; van den Hengel, Berber; Wijma, Allard G.; de Haan, Jael; de Nes, Lindsey C.F.; Heesink, Vera; Karsten, Tom; Heidsma, Charlotte M.; Koemans, Willem J.; Dekker, Jan-Willem T.; van der Zijden, Charlène J.; Roos, Daphne; Demirkiran, Ahmet; van der Burg, Sjirk; Oosterling, Steven J.; Hoogteijling, Tijs J.; Wiering, Bastiaan; Smeeing, Diederik P.J.; Havenga, Klaas; Lutfi, Hamid; Consten, Esther C.J.; Tsimogiannis, Konstantinos; Sköldberg, Filip; Folkesson, Joakim; den Boer, Frank; van Schaik, Ted G.; van Gerven, Pieter; Sietses, Colin; Hol, Jeroen C.; Boerma, Evert-Jan G.; Creemers, Davy M.J.; Schultz, Johannes K.; Frivold, Tone; Riis, Rolf; Gregussen, Hilde; Busund, Sondre; Sjo, Ole H.; Gaard, Maria; Krohn, Nina; Ersryd, Amanda L.; Leung, Edmund; Waqar, Usama; Chawla, Tabish; Rauf, Hareem; Rani, Pallavi; Sultan, Hytham; Hajjaj, Baraa Nabil; Alhisi, Ahmed Jehad; Khader, Ahmed A.E.; Mendes, Ana Filipa Dias; Semião, Miguel; Faria, Luis Queiroz; Azevedo, Constança; da Costa Devesa, Helena M.; Martins, Sónia Fortuna; Rodrigues Jarimba, Aldo M.; Ribeiro Marques, Sónia M.; Ferreira, Rita Marques; Oliveira, António; Ferreira, Cátia; Pereira, Ricardo; Surlin, Valeriu M.; Graure, Giorgiana M.; Ramboiu, Stefan Patrascu Sandu D.; Negoi, Ionut; Ciubotaru, Cezar; Stoica, Bogdan; Tanase, Ioan; Stoica, Bogdan; Ciubotaru, Cezar; Negoita, Valentina M.; Florea, Sabrina; Macau, Florin; Vasile, Mihai; Stefanescu, Victor; Dimofte, Gabriel-Mihail; Luncă, Sorinel; Roată, Cristian-Ene; Mu[Latin Small Letter s with comma below]ină, Ana-Maria; Garmanova, Tatiana; Agapov, Mikhail N.; Markaryan, Daniil G.; Eduard, Galliamov; Yanishev, Alexey; Abelevich, Alexander; Bazaev, Andrey; Rodimov, Sergey V.; Filimonov, Victor B.; Melnikov, Andrey A.; Suchkov, Igor A.; Drozdov, EvgeniyS.; Kostromitskiy, Dmitriy N.; Sjöström, Olle; Matthiessen, Peter; Baban, Bayar; Gadan, Soran; Jadid, Kaveh Dehlaghi; Staffan, Maria; Park, Jennifer M.; Rydbeck, Daniel; Lydrup, Marie-Louise; Buchwald, Pamela; Jutesten, Henrik; Darlin, Lotten; Lindqvist, Ebba; Nilsson, Karl; Larsson, Per-Anders; Jangmalm, Staffan; Košir, Jurij A.; Tomažič, Aleš; Grosek, Jan; Božič, Tajda Košir; Zazo, Aya; Zazo, Rama; Fares, Hala; Ayoub, Kusay; Niazi, Ammar; Mansour, Ali; Abbas, Ayman; Tantoura, Mohammad; Hamdan, Alaa; Hassan, Naya; Hasan, Bassam; Saad, Ahmad; Sebai, Amine; Haddad, Anis; Maghrebi, Houcine; Kacem, Montasser; Yalkın, Ömer; Samsa, Mehmet Veysi; Atak, İbrahim; Balci, Bengi; Haberal, Elifcan; Dogan, Lütfi; Gecim, Ibrahim E.; Akyol, Cihangir; Koc, Mehmet A.; Sivrikoz, Emre; Piyadeoğlu, Deniz; Larkin, John O.; avanagh, Dara O.; Sökmen, Selman; Bişgin, Tayfun; Günenç, Erşan; Güzel, Melek; Leventoğlu, Sezai; Yüksel, Osman; Kozan, Ramazan; Göbüt, Hüseyin; Cengiz, Fevzi; Erdinc, Kemal; Acar, Nihan Coşgun; Kamer, Erdinc; Özgür, İlker; Aydın, Oguzhan; Keskin, Metin; Bulut, Mehmet Türker; Kulle, Cemil B.; Kara, Yasin; Sıbıç, Osman; Özata, İbrahim H.; Buğra, Dursun; Balık, Emre; Kulle, Cemil B.; Çakır, Murat; Alhardan, Anas; Colak, Elif; CiftciEngin Aybar, Ahmet B.; Sari, Ahmet Can; Atici, Semra Demirli; Kaya, Tayfun; Dursun, Ayberk; Calik, Bulent; Özkan, Ömer Faruk; Ülgür, Hanife Şeyda; Düzgün, Özgül; Monson, John; George, Sarah; Woods, Kayla; Al-Eryani, Fatima; Albakry, Rudaina; Coetzee, Emile; Boutall, Adam; Herman, Ayesiga; Warden, Claire; Mugla, Naser; Forgan, Tim; Mia, Imraan; Lambrechts, Anton
Source
Annals of Surgery. Nov 01, 2023 278(5):772-780
Subject
Language
English
ISSN
0003-4932
Abstract
OBJECTIVE:: To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL). BACKGROUND:: AL after RC resection often results in a permanent stoma. METHODS:: This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models’ performance were evaluated. RESULTS:: This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66–0.76). CONCLUSIONS:: The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies.