학술논문
The EuroMyositis registry: an international collaborative tool to facilitate myositis research
Document Type
Academic Journal
Author
Lilleker, James B; Vencovsky, Jiri; Wang, Guochun; Wedderburn, Lucy R; Diederichsen, Louise Pyndt; Schmidt, Jens; Oakley, Paula; Benveniste, Olivier; Danieli, Maria Giovanna; Danko, Katalin; Thuy, Nguyen Thi Phuong; Vazquez-Del Mercado, Monica; Andersson, Helena; De Paepe, Boel; deBleecker, Jan L; Maurer, Britta; McCann, Liza J; Pipitone, Nicolo; McHugh, Neil; Betteridge, Zoe E; New, Paul; Cooper, Robert G; Ollier, William E; Lamb, Janine A; Krogh, Niels Steen; Lundberg, Ingrid E; Chinoy, Hector; D’hose, Sophie; Tian, Xin Lu,xiaolan; Mann, Herman; Kryštufková, Olga; Pleštilová, Lenka; Barochová,katerina kubínová, Martin Klein,tereza; Gelardi, Chiara; Pedini, Veronica; Cardinaletti, Paolo; Jara, Luis J; Saavedra, Miguel A; Cruz-reyes, Claudia V; Vera-lastra, Olga; Andrade-ortega, Lilia; Medrano-ramírez, Gabriel; Satoh, Minoru; Salazar-páramo, Mario; Gomez-bañuelos, Eduardo; Aguilar-arreola, Jorge; Durán-barragán, Sergio; Navarro-hernandez, Rosa Elena; Petri, Marcelo H; Molberg, Øyvind; Dastmalchi, Maryam; Notarnicola, Antonella; Gheorghe, Karina; Rönnelid, Johan; Liden, Maria; Hanna, Balsam; Jalal, Awat; Hellström, Helena; Martineus, Jehns Christian; Ngoc lan, Nguyen Thi; Padyukov, Leonid; New, Paul; Platt, Hazel; Rothwell, Simon; Ahmed, Yasmeen; Armstrong, Raymond; Bernstein, Robert; Black, Carol; Bowman, Simon; Bruce, Ian; Butler, Robin; Carty, John; Chattopadhyay, Chandra; Chelliah, Easwaradhas; Clarke, Fiona; Dawes, Peter; Denton, Christopher; Devlin, Joseph; Edwards, Christopher; Emery, Paul; Fordham, John; Fraser, Alexander; Gaston, Hill; Gordon, Patrick; Griffiths, Bridget; Gunawardena, Harsha; Hall, Frances; Hanna, Michael; Harrison, Beverley; Hay, Elaine; Hilton-jones, David; Horden, Lesley; Isaacs, John; Isenberg, David; Jones, Adrian; Kamath, Sanjeet; Kennedy, Thomas; Kitas, George; Klimiuk, Peter; Knights, Sally; Lambert, John; Lanyon, Peter; Laxminarayan, Ramasharan; Lecky, Bryan; Luqmani, Raashid; Machado, Pedro; Marks, Jeffrey; Martin, Michael; Mcgonagle, Dennis; Mchugh, Neil; Mckenna, Francis; Mclaren, John; Mcmahon, Michael; Mcrorie, Euan; Merry, Peter; Miles, Sarah; Miller, James; Nicholls, Anne; Nixon, Jennifer; Ong, Voon; Over, Katherine; Packham, John; Pipitone, Nicolo; Plant, Michael; Pountain, Gillian; Pullar, Thomas; Roberts, Mark; Sanders, Paul; Scott, David; Scott, David; Shadforth, Michael; Sheeran, Thomas; Srinivasan, Arul; Swinson, David; Teh, Lee-suan; Webley, Michael; Williams, Brian; Winer, Jonathan
Source
Annals of the Rheumatic Diseases. Jan 01, 2018 77(1):30-39
Subject
Language
English
ISSN
0003-4967
Abstract
AIMS: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. METHODS: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. RESULTS: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. CONCLUSION: This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.