학술논문
Serum Inflammatory and Immune Marker Response After Bare-Metal or Drug-Eluting Stent Implantation Following Percutaneous Coronary Intervention
Document Type
Academic Journal
Author
Moohebati, Mohsen; Falsoleiman, Homa; Dehghani, Mashalla; Fazlinezhad, Afsoon; Daloee, Mehdi Hassanzadeh; Esmaeili, Habib; Reza Parizadeh, Seyyed Mohammad; Tavallaie, Shima; Rahsepar, Amir Ali; Paydar, Roghayeh; Reza Kazemi-Bajestani, Seyyed Mohammad; Pourghadam-Yari, Hossein; Rad, Mina Akbari; Zoghdar-Moghadam, Talat; Ghayour-Mobarhan, Majid; Ferns, Gordon A.
Source
Angiology. Feb 01, 2011 62(2):184-190
Subject
Language
English
ISSN
0003-3197
Abstract
ABSTRACT: We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13–84.87) and 77.80 (50.00–84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17–0.49) and 0.21 (0.16–0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = .015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.