학술논문
The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development
Document Type
Academic Journal
Author
Source
American Heart Journal. Apr 01, 2013 165(4):489-500
Subject
Language
English
ISSN
0002-8703
Abstract
Recent advances in electrocardiographic monitoring and waveform analysis have significantly improved the ability to detect drug-induced changes in cardiac repolarization manifested as changes in the QT/corrected QT interval. These advances have also improved the ability to detect drug-induced changes in cardiac conduction. This White Paper summarizes current opinion, reached by consensus among experts at the Cardiac Safety Research Consortium, on the assessment of electrocardiogram-based safety measurements of the PR and QRS intervals, representing atrioventricular and ventricular conduction, respectively, during drug development.