부산대학교 도서관

Background: Dengue infection is still an endemic disease in Indonesia. The hallmark of dengue infection is the posibility to progress to fatal disease. VCAM is known for some role in the pathogenesis of dengue. The aim of the study was To describe VCAM profi le in patients with dengue infection Methods: This study design was cross-sectional study and conducted from January 2012 to November 2013. This study has been approved by Ethical Committee. The subjects were dengue patients with 10 years-old of age or above, with fever on day-1 or day-2, suspected dengue infection according to WHO criteria, showed positive result either by NS-1, and or IgM - IgG. Complete blood count, clinical chemistry, and VCAM were performed on the fi rst day of admission. Correlations were analyzed with Spearman test. Results: We recruited 100 subjects with positive result either by NS-1, and or IgM - IgG, and positive viral load showed. Clinical profi le and laboratory of the subjects were: fever 38±1.03 ℃, hemoglobin 13.57±1.45 g/dL, hematocrite 39.44±4.16 %, leucocyte 3.82x10³ cells/mm3, thrombocyte 98 (min-max 19-312)x10³ cells/mm3, lymphocyte 28.58±12.69%, serum albumin 3.79±0.54 g/dL, VCAM 233 (min-max 60.5-938) ng/ dL. The proportion of thrombocytopenia, hemoconcentration and hypoalbuminemia were 38.6%, 46.5% and 24.8%, respectively. The clinical diagnosis were dengue fever, DHF grade I, and DHF grade grade II; with proportions: 52.5%, 42.6% and 4%, respectively. There were no subject progressing to severe dengue. There were no correlation between VCAM with severity grading, thrombocytopenia, hemoconcentration, hypoalbuminemia, or hemorrhagic events. There were signifi cant weak correlation between VCAM level and body temperature level (r=0.21, p <0.05). Conclusions: We reported VCAM profi le of subjects with mild dengue infection. Signifi cant weak correlation between VCAM level and body temperature level was found in the subjects.