학술논문
한국인 대상 근위축성 측삭경화증의 측정 도구에 따른 효용값 비교: 표준기회선택법과 EQ-5D / Comparison of health utility measures for amyotrophic lateral sclerosis in the general korean population: Standard gamble and EURO QOL-5D
Document Type
Dissertation/ Thesis
Author
Source
Subject
Language
English
Abstract
본 연구는 표준기회선택법(standard gamble, SG)과 EQ-5D (Euro-quality of life five dimensions questionnaire) 등 2 가지 효용 측정 도구를 활용하여 우리나라 일반인을 대상으로 한 근위축성 측삭경화증의 건강 상태별 효용값을 도출하고, 이 2 가지 측정 도구를 통해 도출된 효용값 간 차이에 영향을 미치는 요인을 파악하고자 한다.본 연구는 질환 심각도에 따라 4 단계의 근위축성 측삭경화증 건강상태를 개발하였고, 이는 각각 mild, moderate, severe, terminal로 명명되었다. 각 건강상태별 효용값은 우리나라 일반인 202명을 대상으로 표준기회선택법과 EQ-5D를 통해 측정되었다. 본 연구는 이 2 가지 측정 도구를 통해 도출된 효용값을 paired T-test를 통해 비교하였고, 2 가지 측정 도구를 통해 도출된 효용값의 차이에 대해 각각 질환 심각도와 인구사회학적 요인과의 상관관계를 규명하기 위해 generalized estimating equations를 사용하였다.질환의 심각도가 악화됨에 따라, 표준기회선택법과 EQ-5D를 통해 측정된 효용값은 점차적으로 감소하였다. 표준기회선택법과 EQ-5D로 도출된 각각의 효용값은 근위축성 측삭경화증의 mild 상태를 제외한 모든 건강상태에서 통계적으로 유의한 차이가 있었다: mild 상태, 0.880±0.101 vs. 0.877±0.053 (p=0.716); moderate 상태, 0.787±0.154 vs. 0.722±0.092 (p
This study aimed to elicit health utilities for health states of amyotrophic lateral sclerosis (ALS) in the general population of South Korea using standard gamble (SG) and Euro-quality of life five dimensions questionnaire (EQ-5D) as well as to identify the factors which cause differences in the two utility measures. Four ALS health state descriptions according to disease severity were developed: mild, moderate, severe, and terminal state. Utilities of these states were measured via SG and EQ-5D from 202 respondents, who were selected using a stratified quota sampling method to represent the general Korean population. Utility values from EQ-5D were calculated using a tariff developed for the general population in Korea. Utility values for each health state were compared using paired t-tests, and the relationships between the two utility measures and a level of disease-severity and sociodemographic factors were tested using generalized estimating equations. When disease severity increased, both SG and EQ-5D showed systematic decreases. The utility values between SG and EQ-5D for each state, excluding the mild state, were significantly different: utility value for mild 0.880±0.101 vs. 0.877±0.053 (p=0.716); moderate, 0.787±0.154 vs. 0.722±0.092 (p
This study aimed to elicit health utilities for health states of amyotrophic lateral sclerosis (ALS) in the general population of South Korea using standard gamble (SG) and Euro-quality of life five dimensions questionnaire (EQ-5D) as well as to identify the factors which cause differences in the two utility measures. Four ALS health state descriptions according to disease severity were developed: mild, moderate, severe, and terminal state. Utilities of these states were measured via SG and EQ-5D from 202 respondents, who were selected using a stratified quota sampling method to represent the general Korean population. Utility values from EQ-5D were calculated using a tariff developed for the general population in Korea. Utility values for each health state were compared using paired t-tests, and the relationships between the two utility measures and a level of disease-severity and sociodemographic factors were tested using generalized estimating equations. When disease severity increased, both SG and EQ-5D showed systematic decreases. The utility values between SG and EQ-5D for each state, excluding the mild state, were significantly different: utility value for mild 0.880±0.101 vs. 0.877±0.053 (p=0.716); moderate, 0.787±0.154 vs. 0.722±0.092 (p