부산대학교 도서관

Purpose: We aimed to determine the relationship between environmental exposure and nontuberculous mycobacterial pulmonarydisease (NTM-PD) in Korea. Materials and Methods: A group of 150 patients with NTM-PD and a control group of 217 patients with other respiratory diseaseswere prospectively enrolled between June 2018 and December 2020 in Seoul, Korea. They were surveyed with a standardizedquestionnaire, and their medical records were reviewed. Odds ratio (OR) and 95% confidence intervals (CI) were calculated withmultivariate logistic regression analysis. Results: The mean ages of the NTM-PD and control groups were similar (63.8±9.2 years vs. 63.5±10.0 years; p=0.737), and mostpatients were female (76.0% vs. 68.7%; p=0.157) and nonsmokers (82.0% vs. 72.8%; p=0.021). Mycobacterium avium (49.3%) wasthe most commonly identified strain among NTM-PD patients, followed by M. intracellulare (32.0%) and M. abscessus subspeciesmassiliense (12.7%). There were no differences in housing type or frequency of soil- or pet-related exposure between the case andthe control groups. However, in subgroup analysis excluding patients with M. intracellulare infection, more case patients frequentlyvisited public baths ≥1 time/week (35.3% vs. 19.4%, p=0.003); this remained significant after multivariate analysis (OR, 2.84; 95%CI, 1.58–5.17). Conclusion: Frequent exposure to water at public baths might affect the odds of contracting NTM-PD, excluding individuals infectedwith M. intracellulare strains.