부산대학교 도서관

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the intestine characterized by recurrent chronic inflammation and mucosal damage in the gastrointestinal tract. Recent studies have demonstrated that Aceriphyllum rossii extract (ARE) contains abundant natural flavonoids and enhances the anticancer, antioxidant, and anti-inflammatory effects in various disease models. However, whether ARE has a protective effect against dextran sodium sulfate (DSS)-induced colitis remains unclear. In the present study, we investigated the effects of ARE treatment in a mouse model of colitis. Oral administration of DSS induced shortening of the colon and increased the disease activity index and histological damage. However, ARE treatment significantly attenuated IBD symptoms, such as weight loss, bloody stool, stool consistency, and histological damage in DSS-induced colitis. In addition, ARE treatment decreased colonic inflammatory cytokine (IL-6 and IL-22) levels. Collectively, these results suggest that ARE treatment can help improve colonic function and prevent IBD.