부산대학교 도서관

Prominin-1 (PROM1), also called CD133, is a penta-span transmembraneprotein that is localized in membrane protrusions,such as microvilli and filopodia. It is known to be expressed incancer stem cells and various progenitor cells of bone marrow,liver, kidney, and intestine. Accumulating evidence has revealedthat PROM1 has multiple functions in various organs, such aseye, tooth, peripheral nerve, and liver, associating with variousmolecular protein partners. PROM1 regulates PKA-induced gluconeogenesis,TGFβ-induced fibrosis, and IL-6-induced regenerationin the liver, associating with Radixin, SMAD7, and GP130,respectively. In addition, PROM1 is necessary to maintain cancerstem cell properties by activating PI3K and β-Catenin. PROM1-deficienct mice also show distinct phenotypes in eyes, brain,peripheral nerves, and tooth. Here, we discuss recent findingsof PROM1-mediated signal transduction.