학술논문
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study
Document Type
Journal Article
Author
Akira Narita; Akira Uruno; Atsushi Hozawa; Eiichi N Kodama; Gen Tamiya; Ichiro Tsuji; Ikumi Kanno; Ippei Chiba; Junichi Sugawara; Kotaro Nochioka; Kumi Nakaya; Mami Ishikuro; Mana Kogure; Masato Takase; Masatsugu Orui; Masayuki Yamamoto; Naho Tsuchiya; Naoki Nakaya; Nobuo Fuse; Rieko Hatanaka; Satoshi Nagaie; Shinichi Kuriyama; Soichi Ogishima; Taku Obara; Takumi Hirata; Tomohiro Nakamura; Tomoko Kobayashi; Yohei Hamanaka
Source
Journal of Atherosclerosis and Thrombosis. 2023, 30(12):1950
Subject
Language
English
ISSN
1340-3478
1880-3873
1880-3873
Abstract
Results: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92–7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73–6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65–3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes.