학술논문
Anti-angiogenic and cytotoxic evaluation of green-synthesized [Fe.sub.2]Zn[O.sub.4] nanoparticles against MCF-7 cell line
Document Type
Academic Journal
Author
Source
Biomedical Reports. March 2024, Vol. 20 Issue 3, p1a, 12 p.
Subject
Language
English
ISSN
2049-9434
Abstract
Introduction Nanotechnology, a prominent domain in modern materials science, involves manipulation and comprehension of matter at atomic and molecular scales (1). Nanotechnology and nanoscience center around nanoparticles (NPs) 1-100 nm [...]
The use of plants for nanoparticle (NP) synthesis, grounded in green chemistry principles, is an environmentally friendly and economically viable approach. In the present study, the leaf extract of Elaeagnus angustifolia L. was used as a biosynthetic agent to generate bimetallic zinc oxide NPs. The present study investigated the effect of ZnO NPs on anti-angiogenesis and cell migration. Various bimetallic NPs, including zinc-iron oxide and nickel-zinc oxide, underwent characterization through Fourier-transform infrared spectroscopy and X-ray Diffraction within the 25-65[degrees] range. Confirmation of NP formation was determined by identifying the surface plasmon resonance peak. MTT assay was used to determine the cytotoxic properties of E. angustifolia L. extracts, ZnO NPs and associated metals in MCF-7 breast cancer cells. The plant extract demonstrated antiproliferative effects at 200 [micro]g/ml, whereas E. ang-[Fe.sub.2]Zn[O.sub.4] NPs showed varying cytotoxic effects based on concentration. The rat aortic ring and cell migration assays illuminated anti-angiogenic attributes, with the E. ang-[Fe.sub.2]Zn[O.sub.4] NPs blocking blood vessel development entirely at 100 [micro]g/ml, implying profound anti-angiogenic efficacy. Therefore, E. ang-[Fe.sub.2]Zn[O.sub.4] NPs may serve a role in antiangiogenic therapy.
The use of plants for nanoparticle (NP) synthesis, grounded in green chemistry principles, is an environmentally friendly and economically viable approach. In the present study, the leaf extract of Elaeagnus angustifolia L. was used as a biosynthetic agent to generate bimetallic zinc oxide NPs. The present study investigated the effect of ZnO NPs on anti-angiogenesis and cell migration. Various bimetallic NPs, including zinc-iron oxide and nickel-zinc oxide, underwent characterization through Fourier-transform infrared spectroscopy and X-ray Diffraction within the 25-65[degrees] range. Confirmation of NP formation was determined by identifying the surface plasmon resonance peak. MTT assay was used to determine the cytotoxic properties of E. angustifolia L. extracts, ZnO NPs and associated metals in MCF-7 breast cancer cells. The plant extract demonstrated antiproliferative effects at 200 [micro]g/ml, whereas E. ang-[Fe.sub.2]Zn[O.sub.4] NPs showed varying cytotoxic effects based on concentration. The rat aortic ring and cell migration assays illuminated anti-angiogenic attributes, with the E. ang-[Fe.sub.2]Zn[O.sub.4] NPs blocking blood vessel development entirely at 100 [micro]g/ml, implying profound anti-angiogenic efficacy. Therefore, E. ang-[Fe.sub.2]Zn[O.sub.4] NPs may serve a role in antiangiogenic therapy.