학술논문
Relationship between Newly Diagnosed Hypertensive Patients' Dipping Status and Mean Neutrophil Volume/Yeni Tani Almis Hipertansif Hastalarin Dipping Durumu ile Ortalama Notrofil Hacmi Arasindaki Iliski
Original Article / Ozgun Arastirma
Original Article / Ozgun Arastirma
Document Type
Report
Author
Source
Meandros Medical and Dental Journal. January 2024, Vol. 24 Issue 4, p292, 6 p.
Subject
Language
English
Abstract
Introduction Hypertension (HT) is a major public health concern worldwide, and is considered to be one of the primary causes of preventable deaths. HT has become a disease with high [...]
Objective: Little is known about the pathogenesis of essential hypertension (HT) despite the research conducted in this field. However, similar to other chronic diseases, an association has been shown between HT and inflammation. Thus, this study aimed to explore the association between an indicator of inflammatory response and mean neutrophil volume (MNV) in newly diagnosed hypertensive patients. Materials and Methods: The medical records of patients newly diagnosed with HT were retrospectively reviewed. The control group comprised healthy persons with normal ambulatory blood pressure records. In accordance with their immersion status, newly diagnosed hypertensive patients were divided into two groups. Results: This study included 222 patients: One hundred and forty four patients had HT, and one hundred and eighty-eight were normotensives. HT patients had significantly higher MNV than normotensive patients [144.1 (range: 136.1-152.1 vs.) 140.3 (range: 135.1-145.5), p=0.001], respectively. There were 51 patients with dipper HT and 53 patients with non-dipper HT in the hypertensive group. MNV was significantly higher in the non-dipper HT group [145.7 (range: 138.1-153.46) vs. 142.3 (range: 134.3-150.3), p=0.022], respectively. Multivariate regression analysis demonstrated that MNV [95% confidence interval (CI): 1,006-1,122, p=0.032] and pulse wave velocity (95% CI: 1,203-2,655, p=0.004) were independently correlated with the non-dipping status in newly diagnosed hypertensive patients. Conclusion: Patients with newly diagnosed HT had higher MNV. In addition, increased MNV measurements were associated with non-dipper HT. Keywords: Hypertension, mean neutrophil volume, pulse wave velocity, non-dipper hypertension, MNV Amac: Hipertansiyon (HT) alaninda yapilan arastirmalara ragmen esansiyel HT'nin patogenezi hakkinda cok az sey bilinmektedir. Bununla birlikte, diger kronik hastaliklara benzer sekilde, HT ve enflamasyon arasinda bir iliski gosterilmistir. Bu nedenle, bu calisma yeni tani konmus hipertansif hastalarda bir inflamatuar yanit gostergesi ile ortalama notrofil hacmi (MNV) arasindaki iliskiyi incelemeyi amaclamaktadir. Gerec ve Yontemler: Yeni HT tanisi almis hastalarin tibbi kayitlari retrospektif olarak incelendi. Kontrol grubu, kan basinci kayitlari normal olan saglikli hastalardan olusturuldu. Yeni tani almis hipertansif hastalar, dipping durumlarina gore iki gruba ayrildi. Bulgular: Bu calismaya 222 hasta dahil edildi; 144 hasta yeni HT tanili, 188 hastada ise normotansif olarak degerlendirildi. Hipertansif hastalar, normotansif hastalardan istatistiki olarak daha yuksek MNV'ye sahipti (sirasiyla 144,1, 140,3, p=0,001). Hipertansif grupta dipper HT'si olan 51 hasta ve non-dipper HT olan 53 hasta vardi. MNV, non-dipper HT grubunda anlamli olarak daha yuksekti (sirasiyla 145,7, 142,3, p=0,022). Yeni tani konmus hipertansif hastalarin multivariate regresyon analizinde, MNV'nin [%95 guven araligi (GA): 1,006-1,122, p=0,032] ve nabiz dalga hizinin (%95 CI: 1.203-2.655, p=0,004) non-dipper HT ile iliskili oldugunu gostermistir. Sonuc: Yeni tani konmus hipertansif hastalarda MNV normotansif hastalara gore daha yuksekti. Ek olarak, artan MNV olcumleri non-dipper HT ile iliskiliydi. Anahtar Kelimeler: Hipertansiyon, ortalama notrofil hacmi, nabiz dalga hizi, non-dipper hipertansiyon, MNV
Objective: Little is known about the pathogenesis of essential hypertension (HT) despite the research conducted in this field. However, similar to other chronic diseases, an association has been shown between HT and inflammation. Thus, this study aimed to explore the association between an indicator of inflammatory response and mean neutrophil volume (MNV) in newly diagnosed hypertensive patients. Materials and Methods: The medical records of patients newly diagnosed with HT were retrospectively reviewed. The control group comprised healthy persons with normal ambulatory blood pressure records. In accordance with their immersion status, newly diagnosed hypertensive patients were divided into two groups. Results: This study included 222 patients: One hundred and forty four patients had HT, and one hundred and eighty-eight were normotensives. HT patients had significantly higher MNV than normotensive patients [144.1 (range: 136.1-152.1 vs.) 140.3 (range: 135.1-145.5), p=0.001], respectively. There were 51 patients with dipper HT and 53 patients with non-dipper HT in the hypertensive group. MNV was significantly higher in the non-dipper HT group [145.7 (range: 138.1-153.46) vs. 142.3 (range: 134.3-150.3), p=0.022], respectively. Multivariate regression analysis demonstrated that MNV [95% confidence interval (CI): 1,006-1,122, p=0.032] and pulse wave velocity (95% CI: 1,203-2,655, p=0.004) were independently correlated with the non-dipping status in newly diagnosed hypertensive patients. Conclusion: Patients with newly diagnosed HT had higher MNV. In addition, increased MNV measurements were associated with non-dipper HT. Keywords: Hypertension, mean neutrophil volume, pulse wave velocity, non-dipper hypertension, MNV Amac: Hipertansiyon (HT) alaninda yapilan arastirmalara ragmen esansiyel HT'nin patogenezi hakkinda cok az sey bilinmektedir. Bununla birlikte, diger kronik hastaliklara benzer sekilde, HT ve enflamasyon arasinda bir iliski gosterilmistir. Bu nedenle, bu calisma yeni tani konmus hipertansif hastalarda bir inflamatuar yanit gostergesi ile ortalama notrofil hacmi (MNV) arasindaki iliskiyi incelemeyi amaclamaktadir. Gerec ve Yontemler: Yeni HT tanisi almis hastalarin tibbi kayitlari retrospektif olarak incelendi. Kontrol grubu, kan basinci kayitlari normal olan saglikli hastalardan olusturuldu. Yeni tani almis hipertansif hastalar, dipping durumlarina gore iki gruba ayrildi. Bulgular: Bu calismaya 222 hasta dahil edildi; 144 hasta yeni HT tanili, 188 hastada ise normotansif olarak degerlendirildi. Hipertansif hastalar, normotansif hastalardan istatistiki olarak daha yuksek MNV'ye sahipti (sirasiyla 144,1, 140,3, p=0,001). Hipertansif grupta dipper HT'si olan 51 hasta ve non-dipper HT olan 53 hasta vardi. MNV, non-dipper HT grubunda anlamli olarak daha yuksekti (sirasiyla 145,7, 142,3, p=0,022). Yeni tani konmus hipertansif hastalarin multivariate regresyon analizinde, MNV'nin [%95 guven araligi (GA): 1,006-1,122, p=0,032] ve nabiz dalga hizinin (%95 CI: 1.203-2.655, p=0,004) non-dipper HT ile iliskili oldugunu gostermistir. Sonuc: Yeni tani konmus hipertansif hastalarda MNV normotansif hastalara gore daha yuksekti. Ek olarak, artan MNV olcumleri non-dipper HT ile iliskiliydi. Anahtar Kelimeler: Hipertansiyon, ortalama notrofil hacmi, nabiz dalga hizi, non-dipper hipertansiyon, MNV