학술논문
Stillbirths and Neonatal Deaths Caused by Group B Streptococcus in Africa and South Asia Identified Through Child Health and Mortality Prevention Surveillance (CHAMPS)
MAJOR ARTICLE
MAJOR ARTICLE
Document Type
Academic Journal
Author
Mahtab, Sana; Madewell, Zachary J.; Madhi, Shabir A.; Wise, Amy; Swart, Peter J.; Velaphi, Sithembiso; Mandomando, Inacio; Bramugy, Justina; Mabunda, Rita; Xerinda, Elisio; Scott, Anthony G.; Assefa, Nega; Madrid, Lola; Bweihun, Mulu; Temesgen, Fikremelekot; Onyango, Dickens; Akelo, Victor; Oliech, Richard; Otieno, Peter; Verani, Jennifer R.; Arifeen, Shams El; Gurley, Emily S.; Alam, Muntasir; Rahman, Afruna; Hossain, Mohammad Zahid; Sow, Samba; Kotloff, Karen; Tapia, Milagritos; Keita, Adama Mamby; Sanogo, Doh; Ogbuanu, Ikechukwu; Ojulong, Julius; Lako, Sandra; Ita, Okokon; Kaluma, Erick; Wilson, Tais; Mutevedzi, Portia; Barr, Beth A. Tippett; Whitney, Cynthia G.; Blau, Dianna M.; Bassat, Quique
Source
Open Forum Infectious Diseases. September 2023, Vol. 10 Issue 9
Subject
Language
English
ISSN
2328-8957
Abstract
Mortality in children Group B Streptococcus ([GBS] Streptococcus agalactiae) is a major infectious cause of premature neonatal and early-infancy mortality and could potentially be an overlooked cause of stillborn infants [...]
Background. Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and is also associated with stillbirth. This study aimed to determine the proportion of stillborn infants and infants who died between 0 and 90 days attributable to GBS using postmortem minimally invasive tissue sampling (MITS) in 7 low- and middle-income countries (LMICs) participating in Child Health and Mortality Prevention Surveillance (CHAMPS). Methods. Deaths that occurred between December 2016 and December 2021 were investigated with MITS, including culture for bacteria of blood and cerebrospinal fluid (CSF), multipathogen polymerase chain reaction on blood, CSF, and lung tissue and histopathology of lung, liver, and brain. Data collection included clinical record review and verbal autopsy. Expert panels reviewed all information and assigned causes of death. Results. We evaluated 2966 deaths, including stillborn infants (n = 1322), infants who died during first day of life (0 to Conclusions. Our study reveals significant heterogeneity in the contribution of invasive GBS disease to infant mortality across different countries, emphasizing the need for tailored prevention strategies. Moreover, our findings highlight the substantial impact of GBS on stillbirths, shedding light on a previously underestimated aspect in LMICs. Keywords. death in 24 hours; early neonatal death, stillbirth; minimally invasive tissue sampling (MITS); Streptococcus agalactiae.
Background. Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and is also associated with stillbirth. This study aimed to determine the proportion of stillborn infants and infants who died between 0 and 90 days attributable to GBS using postmortem minimally invasive tissue sampling (MITS) in 7 low- and middle-income countries (LMICs) participating in Child Health and Mortality Prevention Surveillance (CHAMPS). Methods. Deaths that occurred between December 2016 and December 2021 were investigated with MITS, including culture for bacteria of blood and cerebrospinal fluid (CSF), multipathogen polymerase chain reaction on blood, CSF, and lung tissue and histopathology of lung, liver, and brain. Data collection included clinical record review and verbal autopsy. Expert panels reviewed all information and assigned causes of death. Results. We evaluated 2966 deaths, including stillborn infants (n = 1322), infants who died during first day of life (0 to Conclusions. Our study reveals significant heterogeneity in the contribution of invasive GBS disease to infant mortality across different countries, emphasizing the need for tailored prevention strategies. Moreover, our findings highlight the substantial impact of GBS on stillbirths, shedding light on a previously underestimated aspect in LMICs. Keywords. death in 24 hours; early neonatal death, stillbirth; minimally invasive tissue sampling (MITS); Streptococcus agalactiae.