학술논문
Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Document Type
Report
Author
Shyam, Sangeetha; García-Gavilán, Jesús Francisco; Paz-Graniel, Indira; Gaforio, José J.; Martínez-González, Miguel Ãngel; Corella, Dolores; Martínez, J. Alfredo; Alonso-Gómez, Ãngel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López-Miranda, José; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Serra-Majem, J. Luís; Bueno-Cavanillas, Aurora; Tur, Josep A.; Sánchez, Vicente Martín; Pintó, Xavier; Matía-Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K.; Garcia-Regata, Oscar; Toledo, Estefania; Asensio, Eva M.; Castaéer, Olga; Garcia-Rios, Antonio; Torres-Collado, Laura; Gómez-Gracia, Enrique; Zulet, M. Angeles; Ruiz, Nuria Goéi; Casas, Rosa; Cano-Ibáéez, Naomi; Tojal-Sierra, Lucas; Gómez-Perez, A. M.; Sorlí, Jose V.; Cinza-Sanjurjo, Sergio; Martín-Peláez, Sandra; Peéa-Orihuela, Patricia J.; Oncina-Canovas, Alejandro; Perez-Araluce, Rafael; Zomeéo, María Dolores; Chaplin, Alice; Delgado-Rodríguez, Miguel; Babio, Nancy; Fitó, Montserrat; Salas-Salvadó, Jordi
Source
BMC Medicine. October 13, 2023, Vol. 21 Issue 1
Subject
Language
English
ISSN
1741-7015
Abstract
Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HR.sub.adj (95%CI): 1.01 (1.00, 1.03)) and BMI (HR.sub.adj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870). Keywords: Obesity, COVID-19, Older adults, Weight loss, Central obesity
Author(s): Sangeetha Shyam[sup.1,2,3] , Jesús Francisco García-Gavilán[sup.1,2,3] , Indira Paz-Graniel[sup.1,2,3] , José J. Gaforio[sup.4,5] , Miguel Ãngel Martínez-González[sup.1,6,7] , Dolores Corella[sup.1,8] , J. Alfredo Martínez[sup.1,9,10,11] , Ãngel M. Alonso-Gómez[sup.1,12] , [...]
Author(s): Sangeetha Shyam[sup.1,2,3] , Jesús Francisco García-Gavilán[sup.1,2,3] , Indira Paz-Graniel[sup.1,2,3] , José J. Gaforio[sup.4,5] , Miguel Ãngel Martínez-González[sup.1,6,7] , Dolores Corella[sup.1,8] , J. Alfredo Martínez[sup.1,9,10,11] , Ãngel M. Alonso-Gómez[sup.1,12] , [...]