부산대학교 도서관

Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab. Keywords: B lymphocytes, IgG4-related disease, kidney disease, membranous nephropathy
BACKGROUND Renal manifestations of immunoglobulin G4 (IgG4)-releated disease are common and patients typically present with interstitial nephritis [1]. There have been few cases of IgG4-related disease associated with idiopathic membranous [...]