부산대학교 도서관

The role of overall diet on longevity among cancer survivors (CS) needs further elucidation. We performed a systematic review of the literature and a meta-analysis of related cohort studies published up to October 2022 investigating post-diagnosis a priori (diet quality indices) and a posteriori (data-driven) dietary patterns (DPs) in relation to all-cause and cancer-specific mortality. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using random-effects meta-analyses comparing highest versus lowest categories of adherence to DPs. We assessed heterogeneity and risk of bias in the selected studies. A total of 19 cohort studies with 38,846 adult CS, some assessing various DPs, were included in the meta-analyses. Higher adherence to a priori DPs was associated with lower all-cause mortality by 22% (HR = 0.78, 95% CI: 0.73–0.83, I[sup.2] = 22.6%) among all CS, by 22% (HR = 0.78, 95% CI: 0.73–0.84, I[sup.2] = 0%) among breast CS and by 27% (HR = 0.73, 95% CI: 0.62–0.86, I[sup.2] = 41.4%) among colorectal CS. Higher adherence to a “prudent/healthy” DP was associated with lower all-cause mortality (HR = 0.79, 95% CI: 0.64–0.97 I[sup.2] = 49.3%), whereas higher adherence to a “western/unhealthy” DP was associated with increased all-cause mortality (HR = 1.48, 95% CI: 1.26–1.74, I[sup.2] = 0%) among all CS. Results for cancer-specific mortality were less clear. In conclusion, higher adherence to a “healthy” DP, either a priori or a posteriori, was inversely associated with all-cause mortality among CS. A “healthy” overall diet after cancer diagnosis could protect and promote longevity and well-being.
Author(s): Maria-Eleni Spei; Ioannis Bellos; Evangelia Samoli; Vassiliki Benetou (corresponding author) [*] 1. Introduction Cancer survivors form a fast-growing segment of the population worldwide. In 2018, 43.8 million people were [...]